GnT-V调控N-糖基化促进肿瘤恶性表型的研究进展OA
Advances in GnT-V-regulated N-glycosylation and its role in promoting malignant tumor phenotypes
N-乙酰氨基葡萄糖转移酶V/α-1,6-甘露糖糖蛋白6-β-N-乙酰氨基葡萄糖转移酶(alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase,GnT-V/MGAT5)是调控N糖基化的重要酶类之一,负责合成β1,6位糖苷键的N-乙酰氨基葡萄糖胺(β1,6-GlcNAc)支链N-聚糖,参与调控肿瘤细胞的恶性表型.已有研究指出,GnT-V在肿瘤增殖、细胞黏附、侵袭迁移及免疫逃逸等方面扮演重要角色,但其在肿瘤中的详细作用机制尚未得到系统归纳和总结.因此,该文将全面探讨GnT-V如何介入肿瘤细胞恶性进展的调控过程,分析其在肿瘤糖生物学中的关键作用及潜在的临床应用前景,为靶向GnT-V的抗肿瘤药物开发提供理论依据.
GnT-V/MGAT5(alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase),a key enzyme regulat-ing N-glycosylation,is responsible for synthesizing β1,6-GlcNAc-branched N-glycans by catalyzing the formation of β1,6-glycosidic linkages.It plays a significant role in modulating the malignant phenotypes of tumor cells.Although previous studies have demonstrated the involvement of GnT-V in tumor proliferation,cell adhesion,invasion,migration,and immune evasion,its detailed mechanisms of action within tumors have not been systematically reviewed and summarized.Conse-quently,this article comprehensively explores how GnT-V par-ticipates in regulating malignant progression in tumor cells,ana-lyzes its pivotal role in tumor glycobiology,and discusses its po-tential clinical applications.This review aims to provide a theo-retical foundation for developing GnT-V-targeted anti-tumor therapeutics.
韦昕瑀;韦惠兰;黄吉富;蒋木紫;韦姗姗;罗卓;阳洁
广西医科大学药学院,广西 南宁 530021广西医科大学药学院,广西 南宁 530021广西医科大学药学院,广西 南宁 530021广西医科大学药学院,广西 南宁 530021广西医科大学药学院,广西 南宁 530021广西医科大学药学院,广西 南宁 530021广西医科大学药学院,广西 南宁 530021
医药卫生
N-乙酰氨基葡萄糖转移酶VN-糖基化肿瘤增殖黏附侵袭迁移免疫逃逸
N-acetylglucosaminyltransferase VN-glycosyl-ationtumorproliferationadhesioninvasionmetastasisimmune escape
《中国药理学通报》 2026 (4)
623-628,6
国家自然科学基金资助项目(No 8237142603)广西自然科学基金项目重点项目(No 2023GXNSFDA026026)广西自然科学基金杰出青年项目(No 2025GXNSFFA069017)
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