铁死亡在肝脏代谢性疾病中的作用机制研究进展OA

Ferroptosis is an iron-dependent,lipid peroxidation-driven form of regulatory cell death that differs from apoptosis,necrotic apoptosis,pyroptosis,and copper-induced cell death in both biochemical mechanisms and cellular morphological characteristics.This review explores the intrinsic linkages be-tween iron homeostasis,lipid peroxidation,metabolic dysfunction-associated fatty liver disease(MASLD),and its po-tential progression to hepatocellular carcinoma(HCC),based on current research.Research indicates that iron metabolism imbalance—particularly ferroptosis—triggers lipid peroxidation and ferroptosis by generating reactive oxygen species(ROS)via the Fenton reaction.In MASLD,ferroptosis participates in the progression from simple steatosis to metabolic dysfunction-associated steatohepatitis(MASH)and liver fibrosis.In HCC,ferroptosis plays a complex dual role:it functions as an intrinsic tumor suppression mechanism eliminating malignant cells while enabling cancer cells to acquire ferroptosis resistance,thereby promoting tumor progression and inducing tolerance to targeted therapies.Understanding these mechanisms provides potential targets for developing novel therapeutic strategies against both MASLD and HCC.