中医药调控TGF-β及相关信号通路干预早发性卵巢功能不全研究进展OA

Premature ovarian insufficiency(POI)is a common and complex gynecological disorder that significantly impacts patients'physical and mental health.Abnormal activation of transforming growth factor-β(TGF-β)and its signaling pathways can influence pathological processes such as inflammatory responses,oxidative stress,autophagy,and apoptosis,thereby accelerating POI progression.This article reviewed the research progress of TCM regulating TGF-β and related signaling pathways in the treatment of POI from the aspects of Chinese materia medica monomer,compound prescriptions and combination therapy.Research confirms that Chinese materia medica monomers,such as luteolin,poplarin,icariin,and curcumin,as well as TCM prescription,such as Zuogui Pills,modified Yijing Decoction,and Butian Dazao Pills,and the combination of Chinese materia medica with acupuncture,could regulate TGF-β and its associated signaling pathways.These interventions could improve the ovarian tissue microenvironment,alleviate ovarian function decline,and enhance ovarian reserve capacity,which could provide references for TCM intervention in POI research and clinical application.