热敏灸联合耳穴埋豆对气阴两虚型干眼的临床疗效观察OA
Observation on Clinical Efficacy of Heat-sensitive Moxibustion Combined with Au-ricular Point Seed-embedding in the Treatment of Dry Eye with Qi-Yin Deficiency Syn-drome
目的 基于"灸之要,气至有效"理论,观察热敏灸与耳穴埋豆联合应用对气阴两虚型干眼的临床效果.方法 纳入2024年6月—2025年4月就诊于河南省中医院的气阴两虚型干眼患者60例(120只眼),随机分为治疗组和对照组各30例(60只眼).对照组采用0.3%玻璃酸钠滴眼液及王不留行籽耳穴埋豆进行治疗;治疗组在对照组治疗基础上进行热敏灸治疗.分别于治疗前后测量并比较2组患者的泪膜破裂时间(BUT)、泪液分泌试验(SⅠT)、角膜荧光素染色(FL)、中医证候积分及世界卫生组织生存质量测定量表简表(WHOQOL-BREF)评分,并比较2组治疗后的临床疗效.结果(1)BUT:2组治疗后BUT均较治疗前延长,差异均有统计学意义(t治疗组=10.570、t对照组=5.645,均P=0.000);治疗后2组间比较,治疗组BUT长于对照组,差异有统计学意义(t=4.742,P=0.000).(2)SⅠT:2组治疗后SⅠT均较治疗前提高,差异均有统计学意义(t治疗组=12.084,P=0.000、t对照组=3.376,P=0.001);治疗后2组间比较,治疗组SⅠT高于对照组,差异有统计学意义(t=9.777,P=0.000).(3)FL:2组治疗后FL阳性例数均较治疗前减少,差异均有统计学意义(χ2治疗组=23.764,P=0.000;χ2对照组=9.624,P=0.002);治疗后2组间比较,治疗组FL阳性例数少于对照组,差异有统计学意义(χ2=8.571,P=0.003).(4)中医证候积分:2组治疗后中医证候积分均较治疗前降低,差异均有统计学意义(t治疗组=26.923、t对照组=13.869,均P=0.000).治疗后2组间比较,治疗组中医证候积分低于对照组,差异有统计学意义(t=11.358,P=0.000).(5)WHOQOL-BREF评分:2组治疗后WHOQOL-BREF评分均较治疗前提高,差异均有统计学意义(t治疗组=8.811、t对照组=4.880,均P=0.000).治疗后2组间比较,治疗组WHOQOL-BREF评分高于对照组,差异有统计学意义(t=3.906,P=0.000).(6)临床疗效:治疗组总有效率(93.33%)高于对照组(70.00%),差异有统计学意义(χ2=5.455,P=0.020).结论 基于"灸之要,气至有效"理论的热敏灸联合耳穴埋豆对治疗气阴两虚型干眼临床疗效显著,能够有效改善患者的眼表功能,缓解中医证候,并提高患者生活质量.
OBJECTIVE Based on the theory of"The key to moxibustion lies in the arrival of Qi for efficacy",to observe the clinical efficacy of heat-sensitive moxibustion combined with auricular point bean embedding in the treatment of dry eye of Qi-Yin deficiency type.METHODS A total of 60 patients(120 eyes)with dry eye of Qi-Yin deficiency type who were treated in Henan Provincial Hospital of Traditional Chinese Medicine from June 2024 to April 2025 were enrolled and randomly divided into a treatment group(TG)and a control group(CG),with 30 cases(60 eyes)in each group.The control group was treated with 0.3%sodium hyaluronate eye drops combined with vaccaria seed auricular point embedding therapy;on the basis of the treatment of the control group,the treatment group received additional heat-sensitive moxibustion.The tear break-up time(BUT),Schirmer Ⅰ test(S Ⅰ T),corneal fluorescein staining(FL),Traditional Chinese Medicine(TCM)syndrome scores and quality of life scores of the two groups were measured and compared before and after treatment,and the clinical efficacy of the two groups after treatment was also compared.RESULTS(1)BUT:The BUT of both groups was prolonged after treatment compared with that before treatment,with statistically significant differences(tTG=10.570,tCG=5.645,both P=0.000).After treatment,the BUT of the treatment group was longer than that of the control group,with a statistically significant difference(t=4.742,P=0.000).(2)S Ⅰ T:The SⅠT of both groups was increased after treatment compared with that before treatment,with statistically significant differences(tTG=12.084,P=0.000;tCG=3.376,P=0.001).After treatment,the S Ⅰ T of the treatment group was higher than that of the control group,with a statistically significant difference(t=9.777,P=0.000).(3)FL:The number of FL positive cases in both groups was reduced after treatment compared with that before treatment,with statistically significant differences(χ²TG=23.764,P=0.000;χ²CG=9.624,P=0.002).After treatment,the number of FL positive cases in the treatment group were less those in the control group,with a statistically significant difference(χ²=8.571,P=0.003).(4)TCM syndrome scores:The TCM syndrome scores of both groups were decreased after treatment compared with those before treatment,with statistically significant differences(tTG=26.923,tCG=13.869,all P=0.000).After treatment,the TCM syndrome scores of the treatment group were lower than those of the control group,with a statistically significant difference(t=11.358,P=0.000).(5)WHOQOL-BREF scores:The WHOQOL-BREF scores of both groups were increased after treatment compared with those before treatment,with statistically significant differences(tTG=8.811,tCG=4.880,both P=0.000).After treatment,the WHOQOL-BREF scores of the treatment group were higher than those of the control group,with a statistically significant difference(t=3.906,P=0.000).(6)Clinical efficacy:The total effective rate of the treatment group(93.33%)was higher than that of the control group(70.00%),with a statistically significant difference(χ²=5.455,P=0.020).CONCLUSIONS Heat-sensitive moxibustion combined with auricular point bean embedding based on the theory of"The key to moxibustion lies in the arrival of Qi for efficacy"has a significant clinical efficacy in the treatment of dry eye of Qi-Yin deficiency type,which can effectively improve the ocular surface function of patients,relieve TCM syndromes and enhance the quality of life of patients.
齐雪阳;张风梅;赵新;赵方方;白惠仙;杨夏兵
河南省中医院(河南中医药大学第二附属医院),郑州 450002河南省中医院(河南中医药大学第二附属医院),郑州 450002河南省中医院(河南中医药大学第二附属医院),郑州 450002河南省中医院(河南中医药大学第二附属医院),郑州 450002河南省中医院(河南中医药大学第二附属医院),郑州 450002河南省中医院(河南中医药大学第二附属医院),郑州 450002
医药卫生
"灸之要,气至有效"理论热敏灸耳穴埋豆气阴两虚干眼
theory of"the key to moxibustion lies in the arrival of Qi for efficacy"heat-sensitive moxibustionauricular point bean embeddingQi-Yin deficiencydry eye
《中国中医眼科杂志》 2026 (5)
421-425,454,6
河南省中医药科学研究专项课题(2024ZY2082)
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