麦粒灸联合西医常规治疗乙肝肝硬化腹水临床研究OA
Clinical Study on Grain-sized Moxibustion Combined with Conventional Western Medicine for the Treatment of Ascites Due to Cirrhosis of Hepatitis B
目的 观察麦粒灸联合西医常规治疗对乙肝肝硬化腹水的临床效果和安全性.方法 采用随机数字表法将78例乙肝肝硬化腹水患者随机分为试验组和对照组各39例.对照组予西医常规治疗,试验组在此基础上加麦粒灸,均连续治疗10 d,随访3个月.观察2组腹水总有效率,比较2组治疗前后腹围、体质量、24 h尿量、主要症状评分、肝功能指标.监测2组不良反应情况.结果 与对照组比较,试验组总有效率在第11、60、90日均显著增高(P<0.05),2例难治性腹水在第6日达到临床缓解,腹围在第6日、体质量在第90日显著减少(P<0.05),主要症状积分在第60日显著改善(P<0.05),碱性磷酸酶在第11日显著下降(P<0.05);与本组治疗前比较,试验组治疗第6日24 h尿量显著增加(P<0.05),乏力评分在第11、30、60日显著改善(P<0.05),丙氨酸氨基转移酶、天冬氨酸氨基转移酶在第6日显著降低(P<0.05).2组治疗前后血、尿、便常规及肾功能、心电图未见差异性改变,无不良反应报告.结论 在西医常规治疗基础上加用麦粒灸疗法,可提高乙肝肝硬化腹水治疗总有效率,增加尿量、减小腹围和体质量,作用持久;并可改善肝功能及主要症状,尤其对于难治性腹水具有一定疗效,安全性好.
Objective To observe the clinical efficacy and safety of grain-sized moxibustion combined with conventional Western medicine for the treatment of ascites due to cirrhosis of hepatitis B.Methods Totally 78 patients with ascites due to cirrhosis of hepatitis B were randomly divided into experimental group and control group,with 39 cases in each group.The control group received conventional Western medicine treatment,while the experimental group received additional treatment with grain-sized moxibustion for 10 days,with 3-month follow-up.The total effective rates of ascites treatment of both groups were observed,and abdominal circumference,body mass,24-hour urine output,main symptom score,liver function indicators between the two groups were compared.Adverse reactions in two groups were monitored.Results Compared with the control group,the total effective rate of the experimental group significantly increased on days 11,60 and 90(P<0.05).Two cases of refractory ascites achieved clinical remission by day 6,with significant reductions in abdominal circumference on day 6 and body mass on day 90(P<0.05).The total symptom score showed significant improvement on day 60(P<0.05),while the ALP level decreased significantly on day 11(P<0.05);compared with before treatment,the 24-hour urine output in the experimental group increased significantly by day 6(P<0.05),fatigue scores improved significantly on days 11,30 and 60(P<0.05),liver function indicators ALT and AST decreased significantly by day 6(P<0.05).There were no significant differences in blood,urine,stool routine,renal function,and electrocardiogram in the two groups before and after treatment.No adverse reactions were reported.Conclusion The addition of grain-sized moxibustion on the basis of conventional Western medicine treatment can improve the total effective rate of treatment of ascites due to hepatitis B cirrhosis,increase urine volume,reduce abdominal circumference and body mass,and have a lasting effect;it can improve liver function and major symptoms,especially for refractory ascites,with good safety.
李君;周超;刘慧;徐笑;雒琳;秦培洁
中国中医科学院中国医史文献研究所,北京 100700解放军总医院第五医学中心,北京 100039中国中医科学院中国医史文献研究所,北京 100700中国中医科学院中国医史文献研究所,北京 100700中国中医科学院中医临床基础医学研究所,北京 100700中国中医科学院中国医史文献研究所,北京 100700
医药卫生
乙肝肝硬化腹水臌胀艾灸麦粒灸
hepatitis Bcirrhotic ascitestympanitesmoxibustiongrain-sized moxibustion
《中国中医药信息杂志》 2026 (5)
131-136,6
首都卫生发展科研专项(首发2022-2-4311)中国中医科学院基本科研业务费自主选题(ZZ150513、ZZ160505)
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