春泽汤加减治疗良性前列腺增生继发急性尿潴留的临床观察OA
Clinical Study on Modified Chunze Decoction in the Treatment of Acute Urinary Retention Secondary to Benign Prostatic Hyperplasia
目的 观察春泽汤加减治疗良性前列腺增生继发急性尿潴留(脾虚湿阻证)的临床疗效.方法 选取120例患者随机分为对照组(盐酸特拉唑嗪片+春泽汤加减方模拟剂治疗)与观察组(盐酸特拉唑嗪片+春泽汤加减汤方治疗),每组60例.治疗2周后,比较两组临床疗效,观察治疗前后尿动力学指标、前列腺特异抗原(PSA)、热休克蛋白(HSP27、HSP70)、血清炎症因子、中医证候评分、国际前列腺症状量表(IPSS)评分和生活质量评分(QOL)水平变化.结果 治疗后观察组有效率高于对照组(P＜0.05);两组残余尿量(PVR)、膀胱内压均降低,且观察组低于对照组(P＜0.05),两组最大尿流量(Qmax)均升高,且观察组高于对照组(P＜0.05);观察组留置导管时间短于对照组(P＜0.05);两组患者PSA、HSP27、HSP70均下降,且观察组HSP27、HSP70低于对照组(P＜0.05);两组白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)均降低,观察组低于对照组(P＜0.05);两组中医证候评分、IPSS评分和QOL评分均下降,且观察组低于对照组(P＜0.05).结论 春泽汤加减联合盐酸特拉唑嗪片治疗良性前列腺增生继发急性尿潴留(脾虚湿阻证)的临床疗效显著,可改善患者的尿动力学指标,降低热休克蛋白水平,减轻炎症反应,有效缓解患者症状,降低IPSS评分,提高患者生活质量.
Objective:To evaluate the clinical efficacy of Modified Chunze Decoction in treating acute urinary retention secondary to benign prostatic hyperplasia(BPH)with syndrome of damp obstruction due to spleen defi-ciency.Methods:A total of 120 patients were randomly assigned to either the control group(treatment with tam-sulosin hydrochloride tablets+placebo simulating the Modified Chunze Decoction)on the observation group(treat-ment with tamsulosin hydrochloride tablets+Modified Chunze Decoction),with 60 patients in each group.After 2 weeks of treatment,outcomes including clinical efficacy,urodynamic parameters,prostate-specific antigen(PSA),heat shock proteins(HSP27,HSP70),serum inflammatory factors,TCM syndrome scores,International Prostate Symptom Score(IPSS),and quality of life(QOL)scores were compared between the two groups.Results:The to-tal effective rate in the observation group was higher than that in the control group(P＜0.05).After treatment,post-void residual urine volume(PVR)and intravesical pressure decreased in both groups,with significantly great-er reductions in the observation group(P＜0.05);maximum urinary flow rate(Qmax)increased in both groups,with a significantly greater increase in the observation group(P＜0.05).The duration of catheterization was shorter in the observation group than in the control group(P＜0.05).PSA,HSP27,and HSP70 levels decreased in both groups,with significantly lower levels of HSP27 and HSP70 in the observation group(P＜0.05).Serum levels of IL-6,TNF-α,and CRP decreased in both groups,with greater reductions observed in the observation group(P＜0.05).TCM syndrome scores for syndrome of damp obstruction due to spleen deficiency,IPSS,and QoL scores all de-creased in both groups,with significantly greater improvements in the observation group(P＜0.05).Conclusion:Modified Chunze Decoction combined with tamsulosin hydrochloride demonstrates significant clinical efficacy in treating acute urinary retention secondary to BPH with syndrome of damp obstruction due to spleen deficiency.It effectively improves urodynamic parameters,reduces heat shock protein levels,alleviates inflammatory response,re-lieves TCM symptoms,lowers IPSS,and enhances patients' quality of life.
陈一帆;朱枕砚;邓海波;焦守阔;陈武;俞天南
江苏省苏州市中西医结合医院,江苏苏州 215100江苏省苏州市中西医结合医院,江苏苏州 215100江苏省苏州市中西医结合医院,江苏苏州 215100江苏省苏州市中西医结合医院,江苏苏州 215100江苏省苏州市中西医结合医院,江苏苏州 215100江苏省苏州市中西医结合医院,江苏苏州 215100
医药卫生
良性前列腺增生急性尿潴留春泽汤加减脾虚湿阻证随机对照试验
Benign prostatic hyperplasiaAcute urinary retentionModified Chunze DecoctionSyndrome of damp obstruction due to spleen deficiencyRandomized controlled trial
《中国中医急症》 2026 (4)
458-461,4
苏州中西医结合医院科技项目(YJ2023022)
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