Bentall手术体外循环期间血液吸附的临床疗效研究OA

Objective To explore the safety and effectiveness of hemoadsorption during Cardiopulmonary bypass(CPB)in patients underwent Bentall operation.Methods This is a case-control study,focusing on patients who underwent Bentall op-eration with CPB between January 2020 and December 2022.Patients who used intraoperative hemoadsorption with the HA380 cartridge were in the HA group,and patients who were not used in the control group.According to the inclusion and exclusion criteria,225 patients were in the HA group and 179 in the control group.Inflammatory factors,ICU hospitalization time,me-chanical ventilation time,postoperative hospitalization time,etc.were compared between the two groups.SPSS 25.0 statistical software was used for analysis,and Graphpad prism 6.0 software was used for graphing.Results The duration of hospital stay and vasoactive drug use in the HA group were significantly shorter than those in the control group,and the differences were statistically significant(P<0.01).The ECMO usage in the HA group was less than that in the control group,and the difference was statistically significant(P<0.01).At 24 hours and 48 hours after surgery,the levels of IL-6 and IL-8 in the HA group were lower than those in the control group.And three days after surgery,the platelet values of the HA group were significantly lower than those of the control group,and the difference was statistically significant(P<0.01).The ICU length of stay,postoperative plasma transfusion volume and postoperative drainage volume in the HA group were higher than those in the control group,and the differences were statistically significant(P<0.01).Conclusion In this study,we found that intraoperative use of HA380 can significantly reduce the length of hospital stay in Bentall patients,reduce the use of vasoactive drugs,and improve prognosis,and it can significantly reduce plasma IL-6 and IL-8 levels in the early postoperative period.But we should provide prevention and guidance for avoiding complications caused by HA380 resulting in excessive postoperative drainage.