脂联素对动物卵巢衰老的调控作用研究进展OA

Ovarian aging is a normal physiological phenomenon that occurs with the increase of an animal's age.It is manifested by the decline in the quantity and quality of oocytes or follicles,the decrease in the antioxidant capacity of follicles,the increase in the apoptosis of granulosa cells(GCs)and follicular atresia,etc.,which leads to a decrease in reproductive ability.Some pathological damages such as oxidative stress,the decline in DNA repair ability,mitochondrial impairment,and inflammatory response can cause ovarian aging in animals.Adiponectin(ADPN)is a cytokine secreted by adipose tissue.It can delay ovarian aging by regulating various physiological,molecular,and cellular events in the ovary,including the metabolism in ovary,reduction of DNA damage,improvement of mitochondrial function,resistance to inflammation and oxidative stress,regulation of the apoptosis and autophagy of follicular GCs,as well as the secretion of reproductive hormones.This review comprehensively summarizes the mechanisms underlying ovarian aging in animals,the biological functions of ADPN,and its regulatory effects on ovarian aging.It provides critical insights for investigating the potential roles of ADPN in modulating ovarian reserve function,suppressing granulosa cell apoptosis,preventing or delaying ovarian senescence,and enhancing reproductive performance.