膳食类胡萝卜素摄入与便秘患者抑郁症状的关系OA

[Objective]To analyze the association between dietary carotenoid intake and depressive symptoms in individuals with chronic constipation.[Method]Based on data from the 2005-2010 National Health and Nutrition Examination Survey,838 adult patients with chronic constipation were included.Weighted logistic regression,subgroup analysis,and restricted cubic spline were used for investigation.[Result]After comprehensive adjustment for covariates,compared with the lowest tertile,the highest tertile of total dietary carotenoids(OR=0.36,95％CI:0.17-0.74,dietary lycopene(OR=0.31,95％CI:0.14-0.68),and total lycopene(OR=0.30,95％CI:0.14-0.65)was associated with a lower risk of depression(P for trend all<0.05).Subgroup analysis showed that the highest quartile(Q3)of dietary lycopene and total lycopene was significantly and inversely associated with depression risk in the"20-50 years"group,males,those with high school education or above,those with a specific Poverty Income Ratio(PIR),non-obese individuals(BMI<30 kg/m²),and those with lower dietary fiber intake.The highest intake of total dietary carotenoids was significantly and inversely associated with depression risk in the"20-50 years"group,females,those with high school education,those with a higher PIR,non-obese individuals(BMI<30 kg/m²),and those with lower dietary fiber intake.RCS analysis further revealed a nonlinear U-shaped relationship between the intake of total dietary carotenoids and dietary lycopene and depression risk(P-nonlinear=0.007 and 0.031,respectively).[Conclusion]Among patients with chronic constipation,higher intake of carotenoids(especially lycopene)is associated with a lower risk of depression.RCS indicates a nonlinear U-shaped relationship between the intake of total dietary carotenoids and dietary lycopene and depression risk,suggesting that moderate dietary lycopene intake may have potential significance for the mental health of this population.The causal relationship requires further validation by prospective studies.