大学生不同睡眠特征与抑郁症状的关联性分析OA

Objective:This study aims to investigate the associations between sleep duration,bedtime,daytime napping and depressive symptoms among college students.Methods:A total of 812 college students from the 2022 China Family Panel Studies(CFPS)was included.Sleep characteristics were collected via general questionnaires,and depressive symp-toms were evaluated using the 8-item Center for Epidemiologic Studies Depression Scale(CES-D8).To minimize reverse causality and confounding,Mendelian randomization(MR)analysis was conducted to evaluate the potential causal relation-ship between sleep characteristics and the risk of depression using summary statistics from European genome-wide associa-tion studies independent of CFPS data.Results:Multiple linear regression showed that nighttime sleep duration signifi-cantly and negatively predicted depressive symptoms.Restricted cubic spline models further revealed a U-shaped nonlin-ear association between nighttime sleep duration and depressive symptoms.Delayed bedtime was linked to an elevated risk of depressive symptoms.Daytime napping and its duration were not significantly associated with depressive symptoms.MR analysis indicated that short sleep duration was related to an increased risk of depression,and napping was also associated with higher depression risk.Moreover,a stronger preference for morningness was associated with a reduced risk of depres-sion.Conclusion:Insufficient sleep duration and delayed bedtime were both associated with increased depressive symp-toms among college students,and MR results provided causal evidence supporting the observational findings.This study highlights the importance of focusing on sleep behavior patterns in college students to develop more targeted mental health intervention strategies.