鞣花酸缓解畜禽氧化应激的作用机制及应用研究进展OA

Ellagic acid has potent antioxidant activity and is metabolized by gut microbiota into more bio-available urolithins to exert biological effects,thereby alleviating oxidative stress.This article reviewed the metabolic process,metabolites,mechanisms of action,and applications of ellagic acid in production of live-stock and poultry based on the antioxidant mechanism of ellagic acid as the theoretical framework.Ellagic acid contributes to the improvement of semen preservation,oocyte maturation,and the promotion of healthy growth and development in livestock and poultry by metabolizing specific gut microbiota into more bioavailable uro-liths,while inhibiting the generation of reactive oxygen species,activating signaling pathways of antioxidant,improving the barrier function of gut.In the future,focus should be placed on analyzing the interaction network between ellagic acid,gut microbiota and host,and establishing personalized supplementation strategies based on urolithin biomarkers to promote efficient and green development of animal husbandry.