基于倾向性评分匹配法探讨卒中后睡眠障碍对脑血管事件再发风险的影响OA
Influence of sleep disorders after stroke on the risk of recurrence of cerebrovascular events based on propensity score matching
目的 基于倾向性评分匹配法(PSM)探讨卒中后睡眠障碍对脑血管事件再发风险的影响.方法 回顾性分析2021年3月—2023年10月内蒙古自治区精神卫生中心收治的173例脑卒中患者临床资料,根据患者是否存在睡眠障碍将其分为睡眠障碍组(n=88)和非睡眠障碍组(n=85).通过PSM法将两组患者性别、年龄、体重指数(BMI)、烟酒史等基线期资料按照1∶1比例进行匹配,比较匹配前后两组脑血管事件再发情况,采用Cox回归模型分析匹配后卒中后睡眠障碍对脑血管事件再发风险的影响.结果 经PSM法匹配,共有69例匹配成功.匹配后,两组性别、年龄、BMI、饮酒史、吸烟史、既往病史、脑卒中类型、舒张压、收缩压、美国国立卫生院卒中量表评分、三酰甘油、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、空腹血糖、糖化血红蛋白、C-反应蛋白、同型半胱氨酸(Hcy)、焦虑、抑郁比较,差异均无统计学意义(P>0.05).匹配前、匹配后,睡眠障碍组短暂性脑缺血发作以及脑血管事件总发生率均高于非睡眠障碍组(P<0.05).匹配后经Cox回归模型分析得出,卒中后睡眠障碍是脑血管事件再发的独立危险因素(P<0.05).结论 经PSM法匹配脑卒中患者基线期资料后,卒中后睡眠障碍是脑血管事件再发的独立危险因素.
Objective To investigate the influence of sleep disorders after stroke on the risk of recurrence of cere-brovascular events based on propensity score matching(PSM).Methods A retrospective analysis was performed for the clinical data of 173 stroke patients who were admitted to our hospital from March 2021 to October 2023,and according to the presence or absence of sleep disorders,they were divided into sleep disorders group with 88 patients and non-sleep disorders group with 85 patients.The two groups of patients were matched by PSM at a ratio of 1∶1 based on the baseline data of sex,age,body mass index(BMI),and smoking and drinking history,and the recurrence of cerebrovascular events was compared between the two groups before and after matching.The Cox regression model was used to investigate the in-fluence of sleep disorders after stroke on the risk of recurrence of cerebrovascular events after matching.Results A total of 69 cases were successfully matched by PSM.After matching,there were no significant differences between the two groups in sex,age,BMI,drinking history,smoking history,past medical history,stroke type,diastolic blood pressure,systolic blood pressure,National Institutes of Health Stroke Scale score,triglyceride,total cholesterol,low-density lipopro-tein cholesterol,high-density lipoprotein cholesterol,fasting blood glucose,glycosylated hemoglobin,C-reactive protein,homocysteine,anxiety,and depression(P>0.05).Compared with the non-sleep disorders group,the sleep disorders group had a significantly higher incidence rate of transient ischemic attack and a significantly higher overall incidence rate of cerebrovascular events before and after matching(P<0.05).After matching,the Cox regression model analysis showed that sleep disorders after stroke was an independent risk factor for recurrence of cerebrovascular events(P<0.05).Conclusion After PSM of the baseline data of stroke patients,sleep disorder after stroke is an independent risk factor for recurrence of cerebrovascular events.
赵学良;安文瑞;徐丹丹;丛日博
内蒙古自治区精神卫生中心神经内一科,内蒙古 呼和浩特 010000包头市中心医院神经内科,内蒙古 包头 014000内蒙古自治区人民医院血管外科,内蒙古 呼和浩特 010020内蒙古自治区精神卫生中心神经内一科,内蒙古 呼和浩特 010000
医药卫生
脑卒中睡眠障碍脑血管事件危险因素倾向性评分匹配法
StrokeSleep disordersCerebrovascular eventsRisk factorsPropensity score matching
《中风与神经疾病杂志》 2026 (4)
338-342,5
2024公立医院科研联合基金科技项目(2024GLLH0247)
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