大别山牛基因组选择特征分析OA

This study aimed to elucidate the population structure and genetic basis of economic traits of Dabieshan cattle based on whole-genome resequencing.Whole-genome resequencing(10x)was performed on 30 Dabieshan cattle from Jiuhong Agricultural Comprehensive Development Co.,Ltd.in Taihu County,Anhui Province,to detect genetic variation information and structural characteristics.Using the FST and θπ Ratio approach,selective signatures were identified by integrating our data with publicly available whole-genome resequencing from 25 Angus cattle.GO/KEGG enrichment analysis revealed potential biological functions of candidate genes within these selected regions.Genetic variation in the Dabieshan cattle predominantly occurred in non-coding genomic regions,with intergenic and intronic regions accounting for the highest proportions(64.15％and 31.93％,respectively).PCA results indicated distinct population differentiation between Dabieshan cattle and Angus cattle due to genetic background differences.Combined detection using FST and θπ Ratio methods identified 162 selected regions and 130 candidate genes.GO/KEGG enrichment analysis further identified 6 genes(GATM,EGR1,ASAP1,CDC23,EDN3,and PPP1R1B)potentially associated with meat quality traits.This study outlined the genetic structure characteristics of the genome sequence of the Dabieshan cattle,and in-depth explored the genetic differences between the Dabieshan cattle and the Angus cattle at the whole-genome level.It also identified potential selection regions and candidate genes that may affect the population,providing new candidate loci and genes for the conservation and utilization of the genetic resources of the Dabieshan cattle.