血清ATF3、RIPK3、SGLT2水平与老年急性缺血性脑卒中患者NIHSS评分及疾病转归的相关性OA
The Correlation Between Serum ATF3,RIPK3 and SGLT2 Levels with NIHSS Score and Prognosis in Elderly Pa-tients with Acute Ischemic Stroke
目的 探究血清激活转录因子 3(ATF3)、受体相互作用蛋白激酶 3(RIPK3)、钠/葡萄糖协同转运蛋白 2(SGLT2)水平与老年急性缺血性脑卒中(AIS)患者美国国立卫生研究院卒中量表(NIHSS)评分及疾病转归的相关性.方法 选取2023 年1 月至2025 年1 月我院收治的老年 AIS 患者 190 例,根据治疗后疾病转归情况分为预后良好组(n=136)和预后不良组(n=54).ELISA 检测血清 ATF3、RIPK3、SGLT2 水平,收集分析一般临床资料,Logistic 回归分析患者疾病转归的影响因素,绘制受试者工作特征(ROC)曲线分析血清 ATF3、RIPK3、SGLT2 对患者疾病转归的预测价值,Pear-son 法分析 ATF3、RIPK3、SGLT2 水平与 NIHSS 评分的相关性.结果 预后不良组的 ATF3、RIPK3、SGLT2 水平、梗死面积及 NIHSS 评分显著高于预后良好组(P＜0.05);ATF3、RIPK3、SGLT2 水平、梗死面积及 NIHSS 评分升高均为影响患者疾病转归的危险因素(P＜0.05);血清 ATF3、RIPK3、SGLT2 水平与 NIHSS 评分均呈正相关(r=0.523、0.531、0.542,P＜0.05);血清 ATF3、RIPK3、SGLT2 联合预测患者疾病转归的 AUC 显著优于 ATF3(Z=3.248,P=0.001)、RIPK3(Z=3.918,P＜0.001)、SGLT2(Z=3.459,P=0.001)单独预测.结论 血清 ATF3、RIPK3、SGLT2 水平在老年 AIS 预后不良患者中表达均升高,与 NIHSS 评分呈正相关,与疾病转归具有一定预测价值.
Objective To explore the correlation between serum activating transcription factor 3(ATF3),receptor inter-acting protein kinase 3(RIPK3),sodium glucose cotransporter 2(SGLT2)with the National Institutes of Health Stroke Scale(NIHSS)score and prognosis in elderly patients with acute ischemic stroke(AIS).Methods From January 2023 to January 2025,a total of 190 elderly AIS patients admitted to our hospital were included,and were assigned into a good prognosis group(n=136)and a poor prognosis group(n=54)according to the prognosis after treatment.ELISA was used to detect serum ATF3,RIPK3,and SGLT2 levels.General clinical data were collected and analyzed.Logistic regression was used to explore the influencing factors of prognosis.Receiver operating characteristic(ROC)curves were plotted to explore the predictive value of serum ATF3,RIPK3,and SGLT2 for prognosis in patients.Pearson method was used to analyze the correlation between ATF3,RIPK3,SGLT2 levels,and NIHSS score.Results Serum levels of ATF3,RIPK3,SGLT2,infarct size and NIHSS score in the poor prognosis group were significantly higher than those in the good prognosis group(P＜0.05).Elevated levels of ATF3,RIPK3,SGLT2,infarct size,and NIHSS score were all independent risk factors affecting the prognosis of patients(P＜0.05).Serum ATF3,RIPK3,SGLT2 lev-els were positively correlated with NIHSS score(r=0.523,0.531,0.542,P＜0.05).The AUC of the combined detection of serum ATF3,RIPK3 and SGLT2 in predicting prognosis was significantly higher than that of each indicator alone(Z=3.248,P=0.001;Z=3.918,P＜0.001;Z=3.459,P=0.001).Conclusion Serum levels of ATF3,RIPK3,and SGLT2 are elevated in elderly AIS patients with poor prognosis.They are positively correlated with NIHSS score,and has certain predictive value for prognosis.
罗力亚;刘翠青;耿丽洁;刘姗姗;高玉涛
河北省第八人民医院老年科,河北 石家庄 050000河北省第八人民医院老年科,河北 石家庄 050000河北省第八人民医院老年科,河北 石家庄 050000河北省第八人民医院老年科,河北 石家庄 050000河北省第八人民医院老年科,河北 石家庄 050000
医药卫生
激活转录因子3受体相互作用蛋白激酶3钠/葡萄糖协同转运蛋白2老年缺血性脑卒中患者美国国立卫生研究院卒中量表疾病转归
activating transcription factor 3receptor interacting protein kinase 3sodium glucose cotransporter 2elderly patients with acute ischemic strokeNational Institutes of Health Stroke Scaleprognosis
《四川医学》 2026 (4)
377-382,6
河北省卫生和计划生育委员会科研基金项目(编号:20180685)
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