转录组分析融入医学遗传学课程的教学设计OA

There are challenges of complex technical workflows and insufficient integration with clinical diagnostics in the teaching of transcriptomic technologies for the course of medical genetics.To address these issues,the authors develop a teaching framework,which is oriented to precision medicine and centered on transcriptomics.This framework encompasses three interconnected dimensions:fundamental techniques,clinical application,and teaching integration.It comprehensively covers the standard analytical procedures,from data quality control and expression quantification to differential analysis and functional annotation,and it also incorporates real-world diagnostic cases of genetic disorders and public genomic datasets available into teaching practice.With modular design,visualiza-tion tools,and stepwise project-based learning,the framework aims to deepen students'understanding of transcriptomic principles and enhance their ability to apply these techniques to both mechanism research and clinical diagnosis of genetic diseases.The proposed model provides a practical framework to integrate the leading edge and practicality of medical genetics teaching.