栀子豉汤化学成分、药理作用、临床应用研究进展及质量标志物预测分析OA

Zhizichi Decoction(栀子豉汤),which has been used up to the present,was first recorded in Treatise on Cold Damage and Miscellaneous Diseases by ZHANG Zhongjing of the Han Dynasty.It is composed of two medicinal ingredients:Zhizi(Gardeniae Fructus)and Dandouchi(Sojae Semen Praeparatum).It has the functions of clearing depression and relieving annoyance,as well as promoting the release of internal heat.It was originally used to treat the syndrome of"heat stagnation in the chest and diaphragm",with symptoms such as restlessness,insomnia,and chest oppression.Modern research shows that the chemical components of Zhizichi Decoction include iridoids,flavonoids,monoterpenes,diterpenes,triterpenes,organic acids,and organic acid esters,etc.These components often vary due to different processing methods of Zhizi(Gardeniae Fructus)and the fermentation differences of Dandouchi(Sojae Semen Praeparatum).The pharmacological effects mainly focus on the fields of neuroprotection and mental improvement,including anti-depression and hypnotic effects.At the same time,it has anti-inflammatory,antioxidant,antibacterial,regulation of intestinal flora,regulation of endocrine,liver protection,and heart protection effects.It has excellent performance in the nervous system,cardiovascular system,digestive system,respiratory system,endocrine system,and gynecological and pediatric diseases.To make the preparation of Zhizichi Decoction more scientific and standardized,based on the summary and review of its chemical components,pharmacological effects,and clinical applications,the Q-Marker of Zhizichi Decoction was predicted and analyzed in accordance with the five principles of Q-Marker,from the aspects of quality transfer and traceability,specificity,effectiveness,compatibility in compound prescriptions,and measurability.It was determined that geniposide,geniposide acid,geniposide-1-O-β-D-gentiobioside,crocin Ⅰ,daidzein,and genistein are the Q-Markers of Zhizichi Decoction,which can provide a reference basis for the subsequent preparation of Zhizichi Decoction and its related preparations.