DCE-MRI技术在乳腺癌新辅助化疗疗效评估中的应用OA

Objective To investigate the value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)in evaluating the response to neoadjuvant chemotherapy(NAC)for breast cancer.Methods A retrospective analysis was conducted on the clinical data of 102 breast cancer patients who received NAC from December 2021 to December 2023.The patients were divided into the effective group(n=74)and the ineffective group(n=28)based on the chemotherapy outcome.The basic data and quantitative parameters of DCE-MRI[rate constant(Kep),volume transfer constant(Ktrans),extravascular extracellular volume fraction(Ve)]of the two groups were statistically analyzed.Multivariate logistic regression was used to analyze the risk factors for the ineffectiveness of NAC treatment in breast cancer patients.The receiver operating characteristic(ROC)curve was drawn to evaluate the efficacy of DCE-MRI quantitative parameters in predicting the ineffectiveness of NAC treatment in breast cancer patients.Results The proportion of patients with histological grade 2-3 in the ineffective group was higher than that in the effective group.After chemotherapy,Ktrans,Kep and Ve were higher in the ineffective group compared with the effective group(P<0.05).Multivariate logistic regression analysis confirmed that histological grade 2-3,and increased Ktrans,Kep and Ve were all independent risk factors for the ineffectiveness of NAC treatment in breast cancer patients(P<0.05).ROC curve analysis confirmed that Ktrans,Kep and Ve could all be used for the assessment of ineffectiveness of NAC treatment in breast cancer patients,with the areas under the curve of 0.916,0.764,and 0.946,respectively.Conclusion Histological grade 2-3,and increased Ktrans,Kep and Ve all affect the efficacy of NAC in breast cancer patients.Moreover,the quantitative parameters of DCE-MRI have certain value in evaluating the ineffectiveness of NAC treatment in breast cancer patients,and should attract sufficient clinical attention.