拆解-重构策略制备蚕茧基Janus复合止血材料及性能OA
Preparation and Properties of Cocoon-Based Janus Hemostatic Materials via Disassembly-Reconstruction
采用层级结构再组装策略将蚕茧(SC)经剥离、可控溶解、热压复合和疏水改性制得蚕茧基复合止血材料SC-C,利用SEM、FTIR、XRD进行基础表征,并测试了 WCA和WVTR等性能.结果表明SC-C内表面在1.5s内完全吸水,外表面则保持疏水(WCA为119.3 °),WVTR降低至2351g/(m2d),符合伤口敷料最佳范围;Janus结构使得内表面亲水粘附,外表面防止血液过度渗透,SC-C具有良好的血液相容性(HR＜2％),在动物实验中的失血量和止血时间相比于SC和商用水胶体敷料均大幅度降低,表现出优异的止血效果.
A hierarchical reassembly strategy was employed to fabricate a silk cocoon-based composite hemostatic material(SC-C)through processes including delamination,controlled dissolution,hot pressing,and hydrophobic modification.Fundamental characterizations were conducted using SEM,FTIR,and XRD.Water contact angle(WCA)and water vapor transmission rate(WVTR)were also measured.Results showed that the inner surface of SC-C could completely absorb water within 1.5 seconds,while the outer surface remained hydrophobic(WCA=119.3°)The WVTR decreased to 2351 g/(m2 d),falling within the optimal range for wound dressings.The Janus structure allowed the hydrophilic inner surface to adhere to tissue while the hydrophobic outer surface prevented excessive blood permeation.SC-C demonstrated excellent blood compatibility(hemolysis ratio＜2％),and both blood loss and hemostasis time were significantly reduced compared to SC alone and commercial hydrocolloid dressings,indicating outstanding hemostatic performance.
陈茂林;刘向东;付飞亚
浙江理工大学材料科学与工程学院,浙江 杭州 310018浙江理工大学材料科学与工程学院,浙江 杭州 310018浙江理工大学材料科学与工程学院,浙江 杭州 310018||东南大学材料科学与工程学院,江苏 南京 211189||浙江理工大学嵊州创新研究院有限公司,浙江嵊州 312400||浙江理工大学上虞工业技术研究院,浙江上虞 312369
轻工纺织
蚕茧梯度结构止血材料Janus结构
silk cocoongradient structurehemostatic materialJanus structure
《广州化学》 2026 (2)
47-53,7
校企产学研合作项目[低共熔溶剂法回收丝蛋白工艺开发(24210865-J)]
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