三拗汤合止嗽散加味治疗儿童感染后咳嗽的临床研究OA
Clinical Study on Modified San'ao Decoction Combined with Zhisou Powder in Treatment of Post-Infectious Cough in Children
目的:探讨三拗汤合止嗽散加味法治疗儿童感染后咳嗽(post-infectious cough,PIC)的临床疗效.方法:将2023年2月至2024年2月北京中医药大学房山医院收治的120例PIC(风痰恋肺证)患儿采用随机数字表法分为对照组和观察组,每组各60例.对照组采用孟鲁司特钠咀嚼片治疗,观察组采用三拗汤合止嗽散加味治疗,2组患儿均连续治疗10 d.对比2组患儿的临床疗效,观察2组患儿治疗前、治疗后第5、10天的中医证候积分、咳嗽症状积分、咳嗽程度视觉模拟评分法(VAS)评分;并检测治疗前后血清中的免疫球蛋白E(IgE)、白细胞介素-8(IL-8)和肿瘤坏死因子-α(TNF-α)水平.随访30 d,统计2组患儿咳嗽复发及呼吸道感染例数,并记录不良反应发生情况.结果:观察组临床疗效优于对照组(P＜0.05).在治疗过程中,2组患儿于治疗后第5天及第10天的中医证候积分、咳嗽症状积分及咳嗽程度VAS评分均较治疗前下降(P＜0.05),且第10天各项指标低于第5天(P＜0.05);2组治疗后IgE、IL-8和TNF-α水平均较治疗前下降(P＜0.05);观察组在上述时间点的指标改善程度均优于对照组(P＜0.05).治疗后30 d随访期间,2组患儿咳嗽复发及呼吸道感染例数比较差异无统计学意义(P＞0.05).安全性评估结果显示,2组不良反应发生情况比较差异无统计学意义(P＞0.05).结论:三拗汤合止嗽散加味能够通过调节机体免疫功能,减轻气道炎症,从而改善PIC患儿的临床症状.
Objective:To investigate the clinical efficacy of Modified San'ao Decoction Combined with Zhisou Powder in the treatment of post-infectious cough(PIC)in children.Methods:From February 2023 to February 2024,120 children with PIC(wind-phlegm lingering in the lung pattern)admitted to Fangshan Hospital,Beijing University of Chinese Medicine were randomly divided into a control group(60 cases)and an observation group(60 cases).The control group was treated with montelukast sodium chewable tablets,while the observation group was treated with modified San'ao Decoction combined with Zhisou Powder.Both groups were treated continuously for 10 days.The clinical efficacy of the two groups was compared.Traditional Chinese Medicine(TCM)syndrome scores,cough symptom scores,and Visual Analog Scale(VAS)scores were observed before treatment on the 5th and 10th day after treatment.Serum levels of immunoglobulin E(IgE),interleukin-8(IL-8),and tumor necrosis factor-α(TNF-α)were measured before and after treatment.During a 30-day follow-up period,the frequency of cough recurrence and respiratory tract infections were recorded,and the occurrence of adverse reactions was documented.Results:Clinical efficacy differed significantly between the two groups(P＜0.05).During the treatment process,TCM syndrome scores,daytime and nighttime cough symptom scores,and VAS scores in both groups on the 5th and 10th days were significantly lower than baseline(P＜0.05),with greater reductions observed on the 10th day compared to the 5th day(P＜0.05).After treatment,serum levels of IgE,IL-8,and TNF-α were significantly decreased in both groups(P＜0.05).The observation group showed significantly greater improvements in all indicators at the above time points than that in the control group(P＜0.05).During the 30-day follow-up period,no statistically significant differences were found between the two groups in cough recurrence rate,frequency of respiratory tract infections,or overall incidence of adverse reactions(P＞0.05 for all).Conclusion:Modified San'ao Decoction combined with Zhisou Powder can improve clinical symptoms in PIC children by regulating the body's immune-inflammatory response and alleviating airway inflammation,demonstrating a definite therapeutic effect.
游梦祺;韩雪莹;韩少博;李颖;张宏贤;郭书文
北京中医药大学房山医院,北京 102400北京中医药大学房山医院,北京 102400北京中医药大学房山医院,北京 102400北京中医药大学房山医院,北京 102400北京中医药大学房山医院,北京 102400北京中医药大学房山医院,北京 102400
医药卫生
感染后咳嗽风痰恋肺三拗汤止嗽散临床疗效炎症因子
Post-infectious coughwind-phlegm lingering in the lungSan'ao DecoctionZhisou Powderclinical efficacyinflammatory factors
《河北中医药学报》 2026 (2)
17-22,6
北京中医药薪火传承"3+3"工程基层老中医传承工作项目(2023-JC-03)北京中医药大学房山医院2023年度院级项目(K-2023-Y06)
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