外泌体调控视角下火针干预糖尿病周围神经病变的机制探索OA

Diabetic peripheral neuropathy(DPN),a common complication of diabetes mellitus,is clinically characterized by pain,paresthesia,and neurological deficits,which severely impact patients'quality of life and prognosis.Currently,the pathogenesis of DPN remains not fully elucidated.Treatment strategies primarily focusing on glycemic control and symptomatic management offer limited efficacy,and an ideal curative approach is lacking.Fire needling,a traditional Chinese medicine therapy,is believed to activate the qi of the meridians and promote qi and blood circulation through warm stimulation via acupuncture.This paper proposes the hypothesis that fire needling may exert therapeutic effects by activating the secretion of exosomes from local specific cells(such as fibroblasts,immune cells,Schwann cells,etc.).Through regulating gene expression and signaling pathways,it may mediate multiple biological effects including nerve repair,inflammation inhibition,microcirculation improvement,and neuronal protection,ultimately ameliorating the pathological progression of DPN.This hypothesis provides a molecular biology perspective for investigating the mechanisms of acupuncture in traditional Chinese medicine and opens new research directions for exploring the integrated traditional Chinese and western medicine approach to preventing and treating DPN.