补肾强筋胶囊联合抗阻训练对肾虚血瘀型膝骨关节炎的疗效及对下肢肌肉质量的作用OA

Objective To observe the effects of Bushen Qiangjin Capsules combined with resistance training on clinical symptoms,joint function,quality of life,and lower limb muscle mass in patients with early-to-mid-stage knee osteoarthritis(KOA)of kidney deficiency and blood stasis type,and to evaluate its safety and clinical value.Methods A total of 84 patients with early-to-mid-stage KOA of kidney deficiency and blood stasis type who attended the Orthopedics Outpatient Department of Guangdong Second Traditional Chinese Medicine Hospital from February 2025 to August 2025 were enrolled.A random number table was adopted,and the patients were randomly divided into an observation group and a control group,with 42 cases in each group.Both groups received routine basic treatments including health education and lifestyle intervention.On this basis,the control group was treated with resistance training,while the observation group was treated with oral use of Bushen Qiangjin Capsules in addition to the resistance training.The treatment course for both groups was 8 weeks.The changes in pain Visual Analogue Scale(VAS)score,Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)score,Chinese version of the 36-Item Short Form Health Survey(SF-36v2)physical function score,and lower limb muscle mass were observed before and after treatment in both groups.The clinical efficacy and safety of the treatment protocols were evaluated.Results(1)Regarding efficacy,after 8 weeks of treatment,the total effective rate was 90.48%(38/42)in the observation group and 76.19%(32/42)in the control group;intergroup comparison(by rank-sum test)showed that the efficacy in the observation group was significantly superior to that in the control group(P＜0.05).(2)Regarding knee pain,after treatment,the pain VAS scores in both groups were significantly decreased compared with those before treatment(P＜0.01),and the reduction in the observation group was significantly greater than that in the control group(P＜0.01).(3)Regarding knee function,after treatment,the WOMAC scores in both groups were significantly decreased compared with those before treatment(P＜0.01),and the reduction in the observation group was significantly greater than that in the control group(P＜0.05).(4)Regarding basic living ability,after treatment,the SF-36v2 physical function scores in both groups were significantly increased compared with those before treatment(P＜0.01),and the increase in the observation group was significantly greater than that in the control group(P＜0.05).(5)Regarding lower limb muscle mass,after treatment,the muscle mass of the affected lower limb in both groups was significantly increased compared with that before treatment(P＜0.01),and the increase in the observation group was significantly greater than that in the control group(P＜0.05).(6)Regarding safety,during the treatment period,no significant adverse reactions occurred in either group,no abnormalities were observed in blood routine tests,related biochemical indicators,or liver function indicators after 4 and 8 weeks of treatment in both groups,either.Conclusion For patients with early-to-mid-stage KOA of kidney deficiency and blood stasis type,Bushen Qiangjin Capsules combined with resistance training can alleviate pain,improve joint function and quality of life,and also significantly increase lower limb muscle mass.Its clinical efficacy is superior to resistance training alone,with a good safety profile.This indicates that the combined intervention has positive clinical value for these patients.