多酚类天然化合物防治结直肠癌的研究进展OA

Colorectal cancer ranks as the second most common cause of cancer mortality globally.Given the disease's intricate pathogenic mechanisms and the significant adverse effects frequently associated with conventional radiation and chemotherapy,identifying novel natural compounds with minimal toxicity for alternative or complementary therapies has become imperative.Emerging research indicates that natural polyphenols exhibit substantial potential in both the treatment and prevention of colorectal cancer.These compounds may exert their anti-cancer properties through diverse pathways,including inflammation suppression,proliferation inhibition,apoptosis induction,drug resistance modulation,and gut microbiome regulation.This paper synthesizes current advancements in polyphenol-based colorectal cancer research,elucidates their multifaceted anti-tumor mechanisms,and ex-plores strategies to improve their therapeutic bioavailability and targeting specificity,thereby offering innovative perspectives for clinical management.