呼吸道感染伴炎症指标升高患儿维生素A缺乏状况及影响因素分析OA

Objective To investigate the status of serum vitamin A deficiency and its influencing factors for children with respiratory tract infection and concomitant elevated inflammatory markers.Methods A total of 129 children with respiratory tract infection and concomitant elevated inflammatory markers were selected as the infection group,and 66 healthy check-up children during the same period were selected as the control group.Serum vitamin A levels and vitamin A deficiency status were compared between the research subjects of the two groups.General data including demographic characteristics,perinatal indicators,duration of breastfeeding,dietary and daily routine regularity,medical history,lifestyle,and blood biochemical indicators were collected from children in the infection group.Spearman's rank correlation analysis was used to identify the correlations between serum vitamin A levels and white blood cell count(WBC),C-reactive protein(CRP),and procalcitonin(PCT)in children with respiratory tract infection and concomitant elevated inflammatory markers.Multivariate Logistic regression model was adopted to identify the influencing factors for vitamin A deficiency in children with respiratory tract infection and concomitant elevated inflammatory markers.Results The serum vitamin A level in the infection group was lower than that in the control group,and the vitamin A deficiency rate(52.71%)was higher than that in the control group(4.55%)(P<0.05).Spearman's rank correlation analysis results revealed that serum vitamin A levels in the infection group negatively correlated with CRP and PCT(P<0.05),but were not correlated with WBC(P>0.05).Multivariate Logistic regression analysis results indicated that decreased albumin level,decreased prealbumin level,and the history of recurrent respiratory tract infections were risk factors for vitamin A deficiency in children with respiratory tract infection and concomitant elevated inflammatory markers(P<0.05).Conclusion The proportion of children with respiratory tract infection and concomitant elevated inflammatory markers who have serum vitamin A deficiency is relatively high,and it is affected by prealbumin and albumin levels,and the history of recurrent respiratory tract infections.In clinic,early recognition and timely targeted intervention strategies should be formulated to improve the prognosis of these children.