DNA甲基化在宫颈病变中的应用进展OA

Cervical cancer is a common gynecological malignancy that seriously threatens women's health,and its occurrence and development is closely related to persistent infection with high risk human papilloma virus(HR-HPV).Current cervical cancer screening primarily relies on cytological examination and HR-HPV DNA testing.However,the former is subjective and has limited sensitivity,while the latter lacks specificity and may lead to overdiagnosis and overtreatment.DNA methylation,as a crucial epigenetic modification,is involved in the regulation of gene transcription.Recent studies have shown that HR-HPV infection can induce abnormal methylation at specific gene loci in host cells,and these alterations are closely associated with the progression of cervical intraepithelial neoplasia and the occurrence and development of cervical cancer.Detecting the methylation status of these specific genes demonstrates significant potential in triaging cervical cancer screening,prognostic evaluation,and monitoring therapeutic efficacy.This article reviews the application value of DNA methylation in cervical lesions,aiming to provide new insights for the precise prevention and treatment of cervical cancer.