Porphyromonas gingivalis-derived extracellular vesicles aggravate bone destruction in rheumatoid arthritis by promoting Syk-dependent osteoclastogenesisOA
Porphyromonas gingivalis-derived extracellular vesicles aggravate bone destruction in rheumatoid arthritis by promoting Syk-dependent osteoclastogenesis
Jiajie Guo;Kaya Yoshida;Hongchen Sun;Lihong Qiu;Qiujing Qiu;Xiaoyuan Yan;Zeying Zhang;Xiyue Zhang;Na An;Chengcheng Yin;Di Yang;Hirohiko Okamura
Department of Endodontics,School and Hospital of Stomatology,China Medical University,Liaoning Provincial Key Laboratory of Oral Diseases,Shenyang,ChinaDepartment of Oral Healthcare Education,Institute of Biomedical Sciences,Tokushima University Graduate School,Tokushima,JapanDepartment of Oral Pathology,School and Hospital of Stomatology,China Medical University,Liaoning Provincial Key Laboratory of Oral Diseases,Shenyang,ChinaDepartment of Endodontics,School and Hospital of Stomatology,China Medical University,Liaoning Provincial Key Laboratory of Oral Diseases,Shenyang,ChinaDepartment of Endodontics,School and Hospital of Stomatology,China Medical University,Liaoning Provincial Key Laboratory of Oral Diseases,Shenyang,ChinaDepartment of Endodontics,School and Hospital of Stomatology,China Medical University,Liaoning Provincial Key Laboratory of Oral Diseases,Shenyang,ChinaDepartment of Endodontics,School and Hospital of Stomatology,China Medical University,Liaoning Provincial Key Laboratory of Oral Diseases,Shenyang,ChinaDepartment of Endodontics,School and Hospital of Stomatology,China Medical University,Liaoning Provincial Key Laboratory of Oral Diseases,Shenyang,ChinaDepartment of Orthodontics,School and Hospital of Stomatology,China Medical University,Liaoning Provincial Key Laboratory of Oral Diseases,Shenyang,ChinaSchool and Hospital of Stomatology,Jilin University,Changchun,China||Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling,Changchun,ChinaDepartment of Endodontics,School and Hospital of Stomatology,China Medical University,Liaoning Provincial Key Laboratory of Oral Diseases,Shenyang,ChinaDepartment of Oral Morphology,Graduate School of Medicine,Dentistry and Pharmaceutical Sciences,Okayama University,Okayama,Japan
《国际口腔科学杂志（英文版）》 2026 (2)
258-274,17
This work was supported by the China Postdoctoral Science Foundation(2021MD703905),National Natural Science Foundation of China(81900992,81870752,82470970),and Natural Science Foundation of Liaoning Province(2023-BS-097).Figure 3a was created in BioRender.Guo,J.(2025)https://BioRender.com/vu8p4uq.Figure 5a was created in BioRender.Guo,J.(2025)https://BioRender.com/c41e720.Figure 8a was created in BioRender.Guo,J.(2025)https://BioRender.com/t45u769.Figure 13 was created in BioRender.Guo,J.(2025)https://BioRender.com/c79a269.
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