核素分子影像在炎症性肠病诊疗应用中的研究进展OA

Inflammatory bowel disease(IBD)is a group of chronic nonspecific intestinal inflammatory disorders with an undefined etiology.Early diagnosis remains challenging,and severe late-stage complications significantly impair patients'quality of life,making early diagnosis and intervention critical.Commonly used clinical diagnostic methods,such as CT,MRI,ultrasound,and digestive endoscopy,have certain limitations in the early detection of IBD,underscoring an urgent need for sensitive and specific early diagnostic strategies suitable for molecular imaging research.An increasing number of studies have investigated the application of various radionuclide molecular imaging agents,such as WBC,FDG,FAPI,CD45 and CXCR4,in diverse inflammatory diseases.These molecular imaging agents play a pivotal role in early disease diagnosis,inflammatory activity assessment,complication detection,as well as therapeutic response monitoring and prognosis evaluation,exhibiting high potential for clinical translation in molecular imaging practice.This review summarizes the latest research progress of radionuclide molecular imaging in the diagnosis and treatment of IBD,comprehensively analyzes its advantages,disadvantages,and application prospects in the field of molecular imaging,and aims to provide robust evidence to support the clinical application of molecular imaging techniques in IBD diagnosis.