肺部混合磨玻璃结节实性成分的CT参数对肺腺癌浸润程度的预测价值OA
Predictive value of CT parameters of solid components in pulmonary mixed ground-glass nodules for infiltration degree of lung adenocarcinoma
目的 探讨肺部混合磨玻璃结节(mGGN)实性成分的CT参数对肺腺癌浸润程度的预测价值.方法 收集2022年1月～2024年4月我院表现为肺部mGGN且经病理证实的120例肺腺癌患者的临床资料,根据病理诊断结果将浸润性腺癌(IAC)患者纳入IAC组(n=73),非IAC(原位腺癌与微浸润腺癌)患者纳入非IAC组(n=47),比较两组患者基线资料、mGGN实性成分的CT征象及参数,采用ROC曲线分析肺部mGGN实性成分CT参数对IAC的预测价值.结果 IAC组患者年龄、分叶征、毛刺征、空气支气管征比例、mGGN实性成分最大径、平均直径、最大CT值及平均CT值均高于非IAC组(P<0.05).多因素logistic回归分析显示,分叶征、空气支气管征、平均直径、最大CT值及平均CT值是肺腺癌浸润程度的独立影响因素(P<0.05).ROC曲线显示,肺部mGGN实性成分的平均直径、最大CT值及平均CT值预测肺腺癌浸润程度的最佳截断值分别为10.09 mm、-114.00 HU、-394.07 HU,且三者联合预测肺腺癌浸润程度的AUC为0.892,敏感度为89.04％,均高于指标单独预测的AUC及敏感度(P<0.05).结论 肺部mGGN实性成分的CT参数与肺腺癌浸润程度密切相关,其中平均直径、最大CT值联合平均CT值对肺腺癌浸润程度具有较高的预测价值.
Objective To explore the predictive value of CT parameters of solid components in pulmonary mixed ground-glass nodules(mGGN)for infiltration degree of lung adenocarcinoma.Methods The clinical data of 120 patients with lung adenocarcinoma who presented with pulmonary mGGN and were confirmed by pathology from January 2022 to April 2024 were collected.Based on pathological results,patients with invasive adenocarcinoma(IAC)were included in the IAC group(n=73)and those with adenocarcinoma in situ and minimally invasive adenocarcinoma were included in the non-IAC group(n=47).Baseline data,CT signs and parameters of solid components in mGGN were compared between the two groups.ROC curves were used to evaluate the predictive value of CT parameters of solid components in pulmonary mGGN for IAC.Results Compared with the non-IAC group,the IAC group showed older age,higher proportions of lobulation,spiculation and air bronchogram signs,larger maximum diameter,average diameter,maximum CT value and average CT value of solid components(P<0.05).Multivariate logistic regression analysis showed that lobulation sign,air bronchogram sign,average diameter,maximum CT value,and average CT value were independent influencing factors for infiltration degree of lung adenocarcinoma(P<0.05).ROC curves showed that the optimal cutoff values of average diameter,maximum CT value,and average CT value of solid components in pulmonary mGGN for predicting infiltration degree of lung adenocarcinoma were 10.09 mm,-114.00 HU,and-394.07 HU,respectively.The AUC and sensitivity of combination of these three parameters for predicting infiltration degree of lung adenocarcinoma were 0.892 and 89.04％,respectively.Both were higher than those of any parameter alone(P<0.05).Conclusion CT parameters of solid components in pulmonary mGGN are closely related to infiltration degree of lung adenocarcinoma.Among them,the combination of average diameter,maximum CT value,and average CT value demonstrates high predictive value for infiltration degree of lung adenocarcinoma.
朱冉冉;孙家龙;吴宗山;黄道余;武前枝
安徽医科大学附属六安医院/六安市人民医院 医学影像科,安徽 六安 237000安徽医科大学附属六安医院/六安市人民医院 医学影像科,安徽 六安 237000安徽医科大学附属六安医院/六安市人民医院 医学影像科,安徽 六安 237000安徽医科大学附属六安医院/六安市人民医院 医学影像科,安徽 六安 237000安徽医科大学附属六安医院/六安市人民医院 呼吸与危重症医学科,安徽 六安 237000
混合磨玻璃结节实性成分CT参数肺腺癌浸润程度
mixed ground-glass nodulesolid componentCT parameterslung adenocarcinomainfiltration degree
《分子影像学杂志》 2026 (4)
515-521,7
六安市科技局项目(2022lakj019)
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