全氟碳化合物乳液中氧溶解度测定的改良酶促法OA
Determination of Oxygen Solubility in Perfluorocarbon Emulsions by a Modified Enzymatic Method
在全氟碳化合物(perfluorocarbon,PFC)乳液中,氧溶解度是评价其在人工血液、氧气运输、诊断成像剂等领域应用性能的重要指标.然而,目前缺乏简便且准确的检测方法.本文以全氟己基乙基聚氧乙烯醚(perfluorohexylethyl polyoxyethylene ether,FEO)为乳化剂制备了全氟溴辛烷(perfluorooctyl bromide,PFOB)乳液,并开发了一种改良酶促法.该方法采用更稳定的橙黄 G 为显色指示剂来测定在298.15 K 和大气压条件下乳液的氧溶解度.采用该改良酶促法测得 0.2 mL 乳液的氧溶解度与文献中通过气液色谱法得到的结果接近.基于该改良酶促法,进一步探究了 PFOB 和乳化剂质量分数对乳液氧溶解度的影响.结果表明,乳液氧溶解度随着 PFC 质量分数的增加而增加,而与乳化剂质量分数无显著相关性.
Oxygen solubility in perfluorocarbon(PFC)emulsions is a crucial performance metric in fields such as artificial blood,oxygen transportation and diagnostic imaging agents.However,there is a lack of simple and accurate detection methods.In this study,the perfluorooctyl bromide(PFOB)emulsion was prepared by using perfluorohexylethyl polyoxyethylene ether(FEO)as the emulsifier,and a modified enzymatic method was developed by using a more stable Orange G as the color indicator to determine the oxygen solubility in the PFOB emulsion at 298.15 K and atmospheric pressure.For 0.2 mL emulsion,the oxygen solubility measured by the modified enzymatic method was close to that measured by gas-liquid chromatography as reported in the literature.The effects of mass fractions of PFC and FEO in the emulsions on the oxygen solubility were studied based on the modified enzymatic method.The results indicate that the oxygen solubility in the emulsion increases with the increasing mass fraction of PFC,independent of the mass fraction of the emulsifier.
王兴宇;王彪;葛世杰;郭迎馨
东华大学 先进纤维材料全国重点实验室 材料科学与工程学院,上海 201620东华大学 先进纤维材料全国重点实验室 材料科学与工程学院,上海 201620东华大学 先进纤维材料全国重点实验室 材料科学与工程学院,上海 201620东华大学 先进纤维材料全国重点实验室 材料科学与工程学院,上海 201620
化学化工
全氟碳化合物(PFC)乳液氧溶解度酶促法
perfluorocarbon(PFC)emulsionoxygen solubilityenzymatic method
《东华大学学报（英文版）》 2026 (2)
76-81,6
National Key R&D Program of China(No.2020YFB1505700)
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