表观遗传修饰在抗病育种中的应用潜力OA

Disease-resistant breeding is one of the important strategies for animal disease prevention and control.At present,China has made great progress in this area through gene editing technology.But,there are uncertainties in its application transformation,because it may cause human genome confusion.Epigenetic modification is a new method of regulation through DNA,histone or chromosome modification,which has heritability and reversibility,and is a feasible method to solve the biosafety of disease resistance breeding.At present,African swine fever(ASF),porcine reproductive and respiratory syndrome(PRRS)and porcine epidemic diarrhea(PED)disease-related epigenetic modifications were used as breakthrough points to prove the feasibility of pig disease resistance breeding through epigenetic modifications,and provide reference for the transformation applica-tion of disease resistance breeding.