富血小板血浆联合倍他米松在肩袖损伤修复术后的应用及对肩关节活动度的影响OA

Objective:To explore the application of platelet-rich plasma(PRP)combined with betamethasone after rotator cuff injury repair and the impact on shoulder range of motion.Methods:A total of 116 patients who underwent rotator cuff injury repair were selected.They were divided into the control group(n=58,receiving betamethasone treatment)and the observation group(n=58,receiving PRP combined with betamethasone treatment)according to different treatment methods.The pain level[Visual Analog Scale(VAS)scores],shoulder joint range of motion(anteflexion and abduction angles)and function[Constant-Murley Shoulder Score(CMS)],inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),transforming growth factor-β1(TGF-β1)]and incidence of adverse reactions were compared between the two groups.Results:At 1,3,and 6 months postoperatively,the observation group showed a decrease in VAS scores,an increase in shoulder ranges of anteflexion and abduction,and a rise in CMS compared to the control group(P＜0.05).At 1 month postoperatively,the observation group showed lower serum levels of TNF-α,IL-6,and TGF-β1 than the control group(P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion:PRP combined with betamethasone can relieve pain,improve shoulder range of motion,and alleviate inflammatory response in patients after rotator cuff injury repair,with high safety.