Zinc finger protein 154 inhibits the growth and metastasis of cervical cancer cells through inhibiting Wnt/β-catenin signaling by upregulating NLKOA
Cervical cancer represents a significant global health concern affecting women.The global cancer burden data published by the World Health Organization''s International Agency for Research on Cancer(IARC)indicated that the incidence and mortality of cervical cancer were the fourth most common malignancy in females worldwide in 2022[1].DNA methylation is recognized as a pivotal epigenetic mechanism for gene silencing,which may accumulate with disease severity[2].Hypermethylation has been discovered in several tumor suppressor gene(TsG)promoters in human cancers,and further understanding of gene silencing mechanisms has led more studies to consider epigenetic disruption as an important mechanism leading to the silencing of tumor suppressor genes in tumordevelopment[3].
Chulan Yang;Hongyu Zhao;Jing Tuo;Wei Zhao;Zhiwei Zhang;Zemin Pan;Lianghai Wang;Haixuan Zhao;Songhua Zhao;Hongtao Li
Department of Human Anatomy and Embryology,Key Laboratory of Xinjiang Endemic and Ethnic Diseases,Shihezi University School of Medicine,Shihezi 832002,ChinaDepartment of Human Anatomy and Embryology,Key Laboratory of Xinjiang Endemic and Ethnic Diseases,Shihezi University School of Medicine,Shihezi 832002,ChinaDepartment of Biochemistry and Molecular Biology,Key Laboratory of Xinjiang Endemic and Ethnic Diseases,Shihezi University School of Medicine,Shihezi 832002,ChinaDepartment of Pathology,Key Laboratory of Xinjiang Endemic and Ethnic Diseases,Shihezi University School of Medicine,Shihezi 832002,ChinaDepartment of Human Anatomy and Embryology,Key Laboratory of Xinjiang Endemic and Ethnic Diseases,Shihezi University School of Medicine,Shihezi 832002,ChinaDepartment of Biochemistry and Molecular Biology,Key Laboratory of Xinjiang Endemic and Ethnic Diseases,Shihezi University School of Medicine,Shihezi 832002,ChinaDepartment of Pathology,Key Laboratory of Xinjiang Endemic and Ethnic Diseases,Shihezi University School of Medicine,Shihezi 832002,ChinaDepartment of Human Anatomy and Embryology,Key Laboratory of Xinjiang Endemic and Ethnic Diseases,Shihezi University School of Medicine,Shihezi 832002,ChinaDepartment of Human Anatomy and Embryology,Key Laboratory of Xinjiang Endemic and Ethnic Diseases,Shihezi University School of Medicine,Shihezi 832002,China Department of Medical Cell Biology and Genetics,School of Basic Medical Sciences,Southwest Medical University,Luzhou 646000,ChinaDepartment of Human Anatomy and Embryology,Key Laboratory of Xinjiang Endemic and Ethnic Diseases,Shihezi University School of Medicine,Shihezi 832002,China
医药卫生
epigenetic mechanismdna methylationzinc finger proteingene silencingwhichwnt catenin signalingcervical cancerglobal cancer burden datametastasis
《Acta Biochimica et Biophysica Sinica》 2026 (2)
P.458-462,5
supported by the grants from the National Natural Science Foundation of China (No. 81660462)the 2024 Open Project of the Key Laboratory of Endemic and Ethnic High-incidence Disease in Xinjiang, Ministry of Education, China (No. KF202401).
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