ADD domain added new binding partners for the nuclear hub protein ATRXOA
ATRX is a large,multi-domain nuclear protein that functions as a crucial ATP-dependent chromatin remodeler,transcriptional regulator,and guardian of telomeric and genomic integrity[1].As a member of the SWI/SNF family of chromatin remodeling proteins,a primary and well-defined function of ATRX is to facilitate the replication-independent deposition of the histone variant H3.3 at specific genomic loci,predominantly repetitive sequences such as telomeres,pericentromeric heterochromatin,and ribosomal DNA(rDNA).Mutations in the ATRX gene are associated with a severe Xlinked neurodevelopmental disorder and alpha-thalassemia.Moreover,ATRX dysfunction can lead to genomic instability,contributing to the development and progression of various cancers,including gliomas and pancreatic neuroendocrine tumors(Pan-NETs)[2].
Yan Chen;Yang Luo;Jielin Sun;Shouhua Wang;Bingbing Wan
Key Laboratory of Systems Biomedicine(Ministry of Education),Shanghai Center for Systems Biomedicine,Shanghai Jiao Tong University,Shanghai 200240,China Shanghai Key Laboratory of Gene Editing and Cell-based Immunotherapy for Hematological Diseases,Shanghai Jiao Tong University,Shanghai 200240,ChinaKey Laboratory of Systems Biomedicine(Ministry of Education),Shanghai Center for Systems Biomedicine,Shanghai Jiao Tong University,Shanghai 200240,China Shanghai Key Laboratory of Gene Editing and Cell-based Immunotherapy for Hematological Diseases,Shanghai Jiao Tong University,Shanghai 200240,ChinaKey Laboratory of Systems Biomedicine(Ministry of Education),Shanghai Center for Systems Biomedicine,Shanghai Jiao Tong University,Shanghai 200240,China Institute of Translational Medicine,Shanghai Jiao Tong University,Shanghai 200240,ChinaDepartment of General Surgery,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200092,ChinaKey Laboratory of Systems Biomedicine(Ministry of Education),Shanghai Center for Systems Biomedicine,Shanghai Jiao Tong University,Shanghai 200240,China Shanghai Key Laboratory of Gene Editing and Cell-based Immunotherapy for Hematological Diseases,Shanghai Jiao Tong University,Shanghai 200240,China National Center for International Research on Systems Biomedicine(Ministry of Science and Technology),Shanghai Jiao Tong University,Shanghai 200240,China
医药卫生
chromatin remodeling proteinsatelomeric genomic integritychromatin remodelinggenomic instabilityATRXtelomeric integrityribosomal dna rdna mchromatin remodelertranscriptional
《Acta Biochimica et Biophysica Sinica》 2026 (2)
P.463-465,3
supported in part by the grants from Ningbo Science Innovation Yongjiang 2035 Key R&D Program(No.2025Z101 to B.W.)the National Natural Science Foundation of China(No.32170087 to B.W.)the Fundamental Research Funds for the Central Universitiesthe Interdisciplinary Program of Shanghai Jiao Tong University(No.YG2023QNB11 to S.W.&B.W.)。
评论