Role of prion protein in mediating the synaptotoxic effects of tau oligomers:Implications for Alzheimer’s disease and related tauopathiesOA
Alzheimer’s disease(AD)and other tauopathies are characterized by the accumulation of misfolded tau protein,which forms toxic oligomers that contribute to synaptic dysfunction and neuronal loss.Here,we briefly discuss recent findings indicating that the cellular prion protein(PrPC)plays a critical role in mediating the synaptotoxic effects of tau oligomers(TauOs),offering new insights into disease pathogenesis and potential therapeutic strategies.
Roberto Chiesa;Luana Fioriti;Gianluigi Forloni;Claudia Balducci
Department of Neuroscience,Istituto di Ricerche Farmacologiche Mario Negri IRCCS,Milan,ItalyDepartment of Neuroscience,Istituto di Ricerche Farmacologiche Mario Negri IRCCS,Milan,ItalyDepartment of Neuroscience,Istituto di Ricerche Farmacologiche Mario Negri IRCCS,Milan,ItalyDepartment of Neuroscience,Istituto di Ricerche Farmacologiche Mario Negri IRCCS,Milan,Italy
医药卫生
tau oligomers tauos offeringcellular prion protein prpc playstau oligomersneuronal losssynaptic dysfunctiondisease pathogenesistoxic oligomersmisfolded tau proteinwhich
《Neural Regeneration Research》 2026 (8)
P.3527-3528,2
supported by the Italian Ministry of Health grant RF-2021-12372337(to GF and CB).
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