A role for glutathione in Parkinson’s disease modificationOA
Oxidative stress has long been implicated as a driving force in neurodegenerative disease,with studies of human brain tissue and animal models revealing its important role.Parkinson’s disease(PD),in particular,highlights the selective vulnerability of neurons to the insults of reactive oxygen species.The motor symptoms of PD are caused by degeneration of dopamine neurons in the substantia nigra.These neurons experience increased oxidative stress due in part to highly active mitochondria that support their high bioenergetic demand and the generation of reactive oxygen species by dopamine metabolism(Watanabe et al.,2024).
Jessica Keating;Ian Martin
Jungers Center for Neurosciences,Department of Neurology,Oregon Health and Science University,Portland,OR,USAJungers Center for Neurosciences,Department of Neurology,Oregon Health and Science University,Portland,OR,USA Department of Chemical Physiology and Biochemistry,Oregon Health and Science University,Portland,OR,USA
医药卫生
animal modelsdopamine neuronsmotor symptomsglutathionehuman brain tissueParkinsons diseasereactive oxygen speciestheoxidative stress
《Neural Regeneration Research》 2026 (8)
P.3529-3530,2
supported by OHSU Neurology Foundation Funds and NIH Grant R01NS119226 to IM.
评论