Energy stress and adaptation strategy of tumor cells in different microenvironments:from primary tumors to distant metastasesOA
Since the Warburg effect was first described in the 1920s,tumor energy metabolism has been a central focus of cancer research,emerging as a potential therapeutic target.The tumor microenvironment—including blood vessels,immune cells,stromal components,and other cell types-profoundly influences tumor cell metabolism.Variations in energy supply,oxygen availability,nutrient composition,and the accumulation of metabolic waste across different microenvironments challenge tumor cell survival and progression.In response,tumor cells adapt through flexible regulation and reprogramming of metabolic pathways.Although recent studies have explored metabolic adaptation mechanisms in various tumor microenvironments,the full spectrum from primary tumors to distant metastases remains unexplored.This review summarizes energy stress and adaptation maneuvers in tumor cells across different stages of tumor progression and offers a new perspective for comprehensive research to explore therapeutic strategies targeting tumor metabolism.
Mingzhe Xu;Junjie Fei;Zhi-Xiong Xiao;Yong Yi
Center of Growth,Metabolism and Aging,Key Laboratory of Bio-Resource and Eco-Environment,Ministry of Education,College of Life Sciences,Sichuan University,Chengdu 610064,ChinaCenter of Growth,Metabolism and Aging,Key Laboratory of Bio-Resource and Eco-Environment,Ministry of Education,College of Life Sciences,Sichuan University,Chengdu 610064,ChinaCenter of Growth,Metabolism and Aging,Key Laboratory of Bio-Resource and Eco-Environment,Ministry of Education,College of Life Sciences,Sichuan University,Chengdu 610064,ChinaCenter of Growth,Metabolism and Aging,Key Laboratory of Bio-Resource and Eco-Environment,Ministry of Education,College of Life Sciences,Sichuan University,Chengdu 610064,China
医药卫生
tumor microenvironmentenergy stressmetabolic reprogrammingtumor cell survival
《Acta Biochimica et Biophysica Sinica》 2026 (2)
P.201-215,15
supported by the grants from the National Natural Science Foundation of China(No.82073248)the Natural Science Foundation of Sichuan Province(No.2023NSFSC1859)to Y.Y.
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