CdS-enzyme composite promotes photobiocatalytic conversion of plastic-derived lactate to chiral chemicalsOA
The combination of photo-and bio-catalysis in one-pot enables sustainable,visible-light driven cascade reactions for the synthesis of valueadded chiral chemicals under mild conditions.Despite the attractiveness of merging the redox capability of heterogeneous photocatalysts with the excellent enantioselectivity of enzymes,developing such a reaction under one-pot conditions poses a challenge due to catalyst incompatibility.In this study,a cadmium sulfide(CdS)-enzyme composite was engineered for one-pot conversion of plastic-derived lactate into chiral compounds.By coating CdS onto alginate beads,its redox capability for the oxidation of lactate in water under visible light was preserved.The generated pyruvate subsequently underwent enantioselective transformation catalyzed by encapsulated enzymes within the beads,producing(R)-acetoin,L-alanine,or(R)-phenylacetylcarbinol.The core-shell structure of the CdS-enzyme composite protects the enzymes against radical attacks and facilitates recycling,yielding 81% of(R)-acetoin achieved after four reaction cycles.Additionally,we demonstrated an upcycling process converting post-consumer polylactic acid cups into(R)-acetoin.This work introduces a novel approach for integrating photocatalysts and enzymes to synthesize chiral chemicals from end-of-life plastics.
Willy W.L.See;Phuc T.T.Nguyen;Heng Yih Tan;Jie Fu Jeff Zhou;Sie Shing Wong;Kang Zhou;Ning Yan
Department of Chemical and Biomolecular Engineering,National University of Singapore,4 Engineering Drive 4,117585,SingaporeDepartment of Chemical and Biomolecular Engineering,National University of Singapore,4 Engineering Drive 4,117585,Singapore Joint School of National University of Singapore and Tianjin University,Fuzhou,350207,ChinaDepartment of Chemical and Biomolecular Engineering,National University of Singapore,4 Engineering Drive 4,117585,SingaporeDepartment of Chemical and Biomolecular Engineering,National University of Singapore,4 Engineering Drive 4,117585,SingaporeDepartment of Chemical and Biomolecular Engineering,National University of Singapore,4 Engineering Drive 4,117585,SingaporeDepartment of Chemical and Biomolecular Engineering,National University of Singapore,4 Engineering Drive 4,117585,Singapore Cluster of Food,Chemical and Biotechnology,Singapore Institute of Technology,138683,SingaporeDepartment of Chemical and Biomolecular Engineering,National University of Singapore,4 Engineering Drive 4,117585,Singapore Joint School of National University of Singapore and Tianjin University,Fuzhou,350207,China Centre for Hydrogen Innovations,National University of Singapore,Singapore,117580,Singapore
化学化工
Asymmetric synthesisBiocatalysisPhotocatalysisPlastic upcyclingOrganic-inorganic hybrid composites
《Green Energy & Environment》 2026 (2)
P.523-530,8
We thank MOE Tier-2 project(MOE-T2EP10221-0020)from Ministry of EducationSingapore and the National Research Foundation,Singapore,NRF Investigatorship(NRFI07-2021-0015)for the financial support.
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