中医药队列研究中永恒时间偏倚的识别与控制策略OA

This article systematically reviewed the common types and causes of immortal time bias in traditional Chinese medicine(TCM)cohort studies.It is suggested that immortal time bias mainly includes misclassification and erroneous exclusion,which occur when outcome events happen during the time interval between participant enroll-ment and receiving the intervention.These patients are incorrectly assigned to a group or erroneously excluded from outcome observation.Based on the above analysis,specific methods for controlling immortal time bias are discussed.In terms of study design,nested case-control studies and target trial simulations can be used.Regarding statistical methods,time-dependent Cox regression models,Poisson regression models,sensitivity analysis,and landmark ana-lysis can effectively monitor and control immortal time bias.In terms of hardware technology,new detection technolo-gies and wearable devices such as smart wristbands,continuous biosensors like implantable chips,and mobile health applications can fundamentally shorten immortal time and reduce immortal time bias.By using the above-mentioned methods,it will provide methodological references for the effective control of immortal time bias and the development of high-quality clinical research in TCM.