补肾活血方联合灌肠治疗慢性子宫内膜炎合并不孕症对激素、炎症水平以及妊娠结局的影响OA

Objective To observe the effects of Bushen Huoxue Formula(补肾活血方)combined with enema treatment on hormone,inflammation levels and pregnancy outcomes in patients with chronic endometritis complicated with infertility.Method A prospective study was conducted on 102 patients with chronic endometritis who received treatment at Hengshui People's Hospital from July 2022 to March 2024..The patients were divided into a control group and an observation group according to the random number table method,with 51 patients in each group.The control group received Western medicine anti infection treat-ment,while the observation group was treated with a combination of Bushen Huoxue Formula orally and traditional Chinese medi-cine enema for three consecutive menstrual cycles.The traditional Chinese medicine syndrome scores,traditional Chinese medi-cine syndrome efficacy,serum sex hormone and inflammation levels,pregnancy outcomes and adverse reactions were compared be-tween two groups.Results The total effective rate of the observation group(96.08％,49/51)was significantly better than that of the control group(84.31％,43/51),and the difference was statistically significant(P＜0.05).Before intervention,there was no significant difference in the TCM syndrome scores of the main or secondary symptoms between the two groups(P＞0.05).After intervention,compared with those of the control group,the TCM syndrome scores of the main and secondary symptoms in the ob-servation group were significantly down-regulated(P＜0.01).There was no significant difference in the levels of progesterone(P),estradiol 2(E2)or follicle stimulating hormone(FSH)between the two groups before intervention(P＞0.05).After inter-vention,the levels of P and FSH were down-regulated and the E2 levels up-regulated in the two groups and the changes of the observation group was more obvious(P＜0.01).After intervention,the levels of interleukin-1β(IL-1β),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the observation group were significantly down-regulated(P＜0.01).The incidence of adverse reactions in the observation group(15.68％,8/51)showed no significant difference compared to that in the control group(9.80％,5/51)(P＞0.05).Compared with those of the control group,the clinical pregnancy rate and embryo im-plantation rate of the observation group were significantly up-regulated(P＜0.05),while there was no significant difference in ectopic pregnancy rate,miscarriage rate or preterm birth rate between the two groups(P＞0.05).Conclusion The combination of Bushen Huoxue Formula and enema can significantly enhance the therapeutic effect,alleviate the clinical symptoms such as ab-dominal pain and menstrual disorders,regulate the hormone levels,inhibit the inflammatory reactions and improve the pregnancy outcomes of infertile patients with chronic endometritis.