抗心律失常的中药活性成分研究现状、挑战及思考OA

Arrhythmia is a common cardiovascular disease,and drug therapy is the current standard treatment.However,most anti-arrhythmic drugs used clinically are single ion channel blockers,which not only have various side effects but also exhibit individual differences.Therefore,single ion channel blockers cannot fully treat arrhythmia,and multiple ion channel blockade is often a key factor.Chinese medicine has the characteristics and advantages of multi-pathway and multi-target approaches,which align with the ideal treatment principles for arrhythmias.Research has con-firmed that Chinese medicine contains active ingredients with anti-arrhythmic effects.The selection of these active ingre-dients for anti-arrhythmic therapy may not only be superior to Chinese medicine itself but also provides clear compositions and defined targets.Therefore,studying multi-pathway and multi-target anti-arrhythmic active ingredients from Chinese medicine is a promising direction for future research.Based on this,this paper searches databases including CNKI,Wan-fang Data,VIP,SinoMed,PubMed,Web of Science,Cochrane,and Embase to summarize the current status of research on anti-arrhythmic active ingredients in Chinese medicine over the past five years,analyze the deficiencies and challenges in this research,and suggest future research directions to clarify current hotspots and trends.