睑板神经纤维瘤及全身神经纤维瘤病1例并文献复习OA

Neurofibromatosis type Ⅰ(NF1)is a multisystemic genetic disorder caused by mutations in the neurofi-bromatosis protein 1 gene located on chromosome 17.Neurofibromas occurring in the eye are relatively rare,and those in the lid area in particular are difficult to distinguish from other common swellings such as eyelid chalazion.As a result,cli-nicians often lack sufficient experience to properly intervene in patients.In this report,we report the case of a 31-year-old male patient who presented to our hospital with a limited painless swelling in the lateral canthus of the upper lid of his left eye that had persisted for 1 year.He had systemic signs of NF1,including cutaneous neurofibromas and iris Lisch nod-ules,which were biopsied after surgery.During the follow-up period,the patient's postoperative recovery was favorable,and there were no signs recurrence in the eyelid skin at six-month follow-up.In addition to reporting this case,we per-formed a comprehensive literature review of previously reported cases of ocular neurofibromas.