基于氧化应激探究中医药治疗男性不育症的研究进展OA

Male infertility(MI)refers to the failure of a couple to achieve a successful pregnancy after at least 12 months of regular,unprotected sexual intercourse,due to male factors.In recent years,alongside socio-economic development and shifts in lifestyle patterns,the global incidence of MI has shown a concerning upward trend.Its pathogenic mechanisms are highly complex,involving multiple etiologies such as genetic abnormalities,endocrine disorders,reproductive tract infections,varicocele,immunological factors,adverse lifestyle habits,and environmental exposures. Emerging research further indicates that oxidative stress serves as a core pathological link underlying many of these diverse causes. Contemporary medicine primarily employs pharmacological,surgical,and assisted reproductive technologies (ART) to treat MI. While these approaches have achieved certain success,they present limitations,including difficulty in addressing some root causes,drug side effects,surgical risks,the high cost of ART,and associated ethical controversies. In this context,traditional Chinese medicine (TCM),guided by its unique theoretical framework emphasizing a holistic perspective and syndrome differentiation,exhibits systematic advantages through multi-component,multi-target,and multi-pathway comprehensive interventions.TCM has accumulated substantial clinical experience in improving semen parameters and enhancing natural pregnancy rates in MI patients.A significant body of evidence suggests that the therapeutic mechanisms of TCM for MI are closely related to its potent antioxidant effects,primarily involving the enhancement of antioxidant enzyme activity,inhibition of lipid peroxidation,and promotion of oxidative stress product clearance. To better summarize advances in this field,this article comprehensively reviews and elaborates on recent experimental and clinical research progress regarding the antioxidative stress effects of TCM interventions for MI. The review is organized around several key aspects:active herbal monomers,compound herbal formulations,patented Chinese medicines,acupuncture,and integrated therapeutic approaches. The aim is to provide a reference for subsequent research and clinical practice.