基于微小核糖核酸及相关信号通路探究中医药治疗脓毒症的研究进展OA

Sepsis is a systemic inflammatory response syndrome(SIRS)caused by the invasion of the body by pathogenic microorganisms such as bacteria.Its pathogenesis is complex and closely associated with the pathophysiological changes of multiple systems and organs in the body.As important regulatory factors,microRNAs(miRNAs)participate in cellular biological processes including proliferation,apoptosis,differentiation,and survival,which are crucial for gene regulation in organisms and possess predictive value for various diseases.Studies have confirmed that miRNAs can mediate inflammatory response,immune regulation,and oxidative stress processes,and are closely related to signaling pathways such as JAK-STAT,NF-κB,and PI3K/Akt,playing a key role in the occurrence and development of sepsis.Currently,antibiotics remain the dominant first-line therapeutic drugs for sepsis.However,a series of problems arising from the long-term use of antibiotics have gradually emerged.In recent years,with the continuous advancement of science and technology,significant progress has been made in the research of traditional Chinese medicine(TCM)in the field of sepsis treatment.TCM monomers(e.g.,phillyrin,ginsenoside,baicalein),TCM compound prescriptions[e.g.,Huayu Fang(化瘀方),Shengjiang San(升降散),Xuebijing injection(血必净注射液)],and TCM external therapies can regulate the release of inflammatory factors such as TNF-α,IL-6,and IL-1β,improve oxidative stress indicators including the activities of SOD and GSH as well as the content of MDA,inhibit abnormal apoptosis of target organ cells,and protect the functions of vital organs such as the heart,lungs,and kidneys by upregulating or downregulating the expression of specific miRNAs.This article systematically reviews the association between miRNAs and sepsis-related signaling pathways as well as the mechanisms by which TCM regulates miRNAs,and summarizes the intervention effects of TCM monomers,TCM compounds/preparations,and TCM external therapies.It aims to open up new avenues for TCM treatment of sepsis and provide a useful reference for improving the survival rate and quality of life of patients.