附子山萸汤治疗慢性阻塞性肺疾病急性加重期痰浊阻肺证临床疗效观察OA
Clinical observation of Fuzi Shanyu Tang in treating AECOPD in patients with phlegm-turbidity obstructing the lung syndrome
目的:探讨运气思想指导下附子山萸汤在慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)痰浊阻肺证中的作用.方法:选择达州市中西医结合医院 60 例 AECOPD 患者,并按照患者的治疗意向分为试验组 30 例、对照组 30 例,对照组予以西医综合疗法,试验组在此基础上加用附子山萸汤治疗.观察治疗前后两组的炎性指标、动脉血气的变化情况,观察两组患者的中医症状积分变化并进行临床疗效评价.结果:治疗后,试验组白细胞计数(white blood cell,WBC)、中性粒细胞百分比(neutrophil percentage,NEUT%)、超敏 C 反应蛋白(hypersensitive C-reactive protein,hs-CRP)数值下降明显,且均明显低于对照组(P＜0.05);治疗后,试验组动脉血氧分压(partial pressure of oxygen,PaO2)、血氧饱和度(oxyhemoglobin saturation,SaO2)均升高显著,且均高于对照组,动脉血二氧化碳分压(partial pressure of carbon dioxide,PaCO2)明显降低,且低于对照组,差异有统计学意义(P＜0.05);治疗后,试验组中医证候积分明显低于对照组(P＜0.05),总有效率高于对照组(P＜0.05).结论:附子山萸汤加减治疗 AECOPD 痰浊阻肺证具有明显的抗炎作用,能有效抑制呼吸道的炎性反应,减轻临床症状,改善血液生化指标,提高患者的生活质量.
Objective:The present study aims to explore the role of Fuzi Shanyu Tang(附子山萸汤)in the treatment of phlegm-turbidity obstructing the lung syndrome in acute exacerbation of chronic obstructive pulmonary disease(AECOPD),as guided by the theory of Qi(气)movement.Methods:A total of 60 patients diagnosed with AECOPD of phlegm-turbidity obstructing the lung syndrome were selected from Dazhou Hospital of Integrated Traditional Chinese and Western Medicine.Based on their medication intention,the patients were divided into two groups,the experimental group and the control group,with 30 cases in each group.The control group received conventional Western medicine therapy,while the experimental group received additional treatment with Fuzi Shanyu Tang on this basis.Changes in inflammatory indicators and arterial blood gases were observed before and after treatment in both groups.Furthermore,changes in traditional Chinese medicine(TCM)symptom scores were observed in both groups to evaluate the clinical efficacy.Results:Following the administration of treatment,significant decreases in WBC,NEUT%,and hs-CRP were observed in the experimental group compared to the control group(P<0.05).Additionally,notable increases in PaO2 and SaO2 were evident in the experimental group following treatment,with levels higher than those in the control group.Conversely,a significant reduction in PaCO2 was noted in the experimental group with levels lower than the control group(P<0.05).Furthermore,TCM syndrome scores in the experimental group showed a substantial decrease,indicating a greater efficacy compared to the control group(P<0.05).The experimental group also demonstrated a higher rate of effectiveness compared with the control group(P<0.05).Conclusion:The modified Fuzi Shanyu Tang,exerts a significant anti-inflammatory effect in the treatment of phlegm-turbidity obstructing the lung syndrome in AECOPD.The decoction has been demonstrated to effectively inhibit airway inflammation,alleviate clinical symptoms,improve arterial blood gas indicators,and enhance quality of life of patients.
蒋明君;冉唯君;熊浪
达州市中西医结合医院,四川 达州,635000达州市中西医结合医院,四川 达州,635000达州市中西医结合医院,四川 达州,635000
医药卫生
慢性阻塞性肺疾病痰浊阻肺证附子山萸汤动脉血气炎症因子
Chronic obstructive pulmonary diseasePhlegm-turbidity obstructing the lung syndromeFuzi Shanyu TangArterial blood gasInflammatory factor
《中医临床研究》 2026 (8)
49-54,6
国家高质量发展示范项目—老年健康服务体系项目(01202425).
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