清肺化痰汤治疗慢性阻塞性肺疾病痰热郁肺证患者疗效观察及其机制探讨OA

Objective:To analyze the clinical efficacy and the changes in serum inflammatory factors(IL-1,IL-6,TNF-α)and HIF-1α protein concentrations in patients with chronic obstructive pulmonary disease(COPD)with the phlegm-heat stagnation in the lung syndrome administered Qingfei Huatan Tang(清肺化痰汤).Additionally,to preliminarily explore the mechanisms of Qingfei Huatan Tang on the HIF-1 signaling pathway.Methods:This study included 60 patients with acute exacerbation of COPD,with the traditional Chinese medicine syndrome type of phlegm-heat stagnation in the lung.They were randomly divided into a treatment group and a control group,with 30 cases in each group.The control group received conventional Western medical therapy alone.The treatment group received conventional Western medical therapy combined with Qingfei Huatan Tang.The course of treatment for all patients was a 10-day period.Serum samples were collected from patients at admission and before discharge,and the levels of HIF-1α,IL-1,IL-6,and TNF-α in the serum were quantitatively measured in the laboratory using a biotin-labeled double-antibody sandwich enzyme-linked immunosorbent assay(ELISA).Results:The total effective rate in both groups was over 90%,with the cure rate in the treatment group(86.7%)which was significantly higher than that of the control group(66.7%).The treatment group showed significant improvement in the total score of traditional Chinese medicine(TCM)syndrome compared to the control group(P<0.05).The CAT scores decreased more significantly in the treatment group than those in the control group.Furthermore,the reductions in HIF-1α protein and inflammatory factors(IL-1,IL-6,TNF-α)in the treatment group were significantly greater than those in the control group(P<0.05).Conclusion:Compared with Western medical treatment alone,the combination of Qingfei Huatan Tang with Western medicine can more significantly improve the clinical symptoms,signs,and inflammatory responses in patients with phlegm-heat stagnation syndrome of acute exacerbation of COPD,showing superior efficacy.HIF-1α is a core protein factor through which cells sense and adapt to hypoxic environments,and Qingfei Huatan Tang can significantly reduce HIF-1α protein concentration,alleviating inflammation and symptoms.This demonstrates that the combination of Qingfei Huatan Tang with Western medicine can act on the HIF-1 signaling pathway and effectively improve the symptoms of patients with phlegm-heat stagnation syndrome of COPD.