自拟"轻肝饮"联合宫廷灸治疗痰瘀互结型代谢相关脂肪性肝病的疗效观察OA
Therapeutic efficacy of Qing Gan Yin combined with imperial moxibustion in the treatment of metabolic dysfunction-associated fatty liver disease with phlegm-blood stasis syndrome
目的:观察轻肝饮联合宫廷灸治疗痰瘀互结型代谢相关脂肪性肝病(metabolic dysfunction-associated fatty liver disease,MAFLD)的临床疗效.方法:选择60例痰瘀互结型MAFLD 患者,随机分为治疗组和对照组,每组30例.对照组予膈下逐瘀汤合二陈汤,治疗组予轻肝饮联合宫廷灸,两组疗程均为12 周.分别于治疗前后收集两组的中医证候积分、肝脏脂肪受控衰减参数(controlled attenuation parameter,CAP)、体质量指数(body mass index,BMI)、体质量、腰围、丙氨酸氨基转移酶(alanine aminotransferase,ALT)、天冬氨酸氨基转移酶(aspartate aminotransferase,AST)、总胆固醇(total cholesterol,TC)、三酰甘油(triglyceride,TG)、高密度脂蛋白胆固醇(high-density lipoprotein,HDL-C),并作出疗效评价.结果:治疗后两组中医证候积分均较治疗前降低(P＜0.01),且治疗组优于对照组(P＜0.01),治疗组总有效率高于对照组,差异具有统计学意义(P＜0.05).治疗后两组CAP、BMI、体质量、腰围、ALT、AST、TC、TG水平均较治疗前降低(P均＜0.05),HDL-C水平较前升高(P＜0.05),且治疗组CAP、BMI、体质量、腰围、ALT、AST、TC、TG 疗效水平优于对照组(P均＜0.05).结论:轻肝饮联合宫廷灸治疗痰瘀互结型MAFLD 疗效更优,能更有效地缓解症状,减轻体质量和腰围,改善肝脏脂变程度、肝功能和血脂水平.
Objective:To observe the clinical efficacy of Qing Gan Yin(轻肝饮)combined with imperial moxibustion in treating metabolic dysfunction-associated fatty liver disease(MAFLD)with phlegm-stasis syndrome.Methods:A total of 60 patients with MAFLD phlegm-blood stasis syndrome were randomly divided into the treatment group(n=30)and the control group(n=30).The control group received Gexia Zhuyu Tang(膈下逐瘀汤)combined with Er Chen Tang(二陈汤),while the treatment group received Qing Gan Yin combined with imperial moxibustion.The total treatment course was 12 weeks.Traditional Chinese medicine(TCM)syndrome scores,controlled attenuation parameter(CAP)for liver fat,body mass index(BMI),body weight,waist circumference,alanine aminotransferase(ALT),aspartate aminotransferase(AST),total cholesterol(TC),triglycerides(TG),and high-density lipoprotein cholesterol(HDL-C)were measured before and after treatment for efficacy evaluation.Results:After treatment,both groups showed a significant reduction in TCM syndrome scores compared to baseline(P<0.01),with the treatment group demonstrating superior improvement over the control group(P<0.01).The total effective rate was higher in the treatment group than in the control group(P<0.05).Post-treatment,CAP,BMI,body weight,waist circumference,ALT,AST,TC,TG decreased significantly,and HDL-C levels increased significantly in both groups(all P<0.05),with the treatment group showing greater improvement in CAP,BMI,weight,waist circumference,ALT,AST,TC,TG,and HDL-C compared to the control group(all P<0.05).Conclusion:Qing Gan Yin combined with imperial moxibustion exhibits superior efficacy in treating MAFLD with phlegm-blood stasis syndrome,which more effectively alleviates symptoms,by reducing body weight and waist circumference,and improving CAP,liver function,and lipid profiles.
马奕湲;张汪来;王雅倩;姜晓华;李猛
安徽中医药大学,安徽 合肥,230012||安徽中医药大学附属铜陵市中医医院,安徽 铜陵,244000安徽中医药大学附属铜陵市中医医院,安徽 铜陵,244000安徽中医药大学,安徽 合肥,230012||安徽中医药大学附属铜陵市中医医院,安徽 铜陵,244000安徽中医药大学附属铜陵市中医医院,安徽 铜陵,244000安徽中医药大学附属铜陵市中医医院,安徽 铜陵,244000
医药卫生
代谢相关脂肪性肝病痰瘀互结证旋覆花汤膈下逐瘀汤宫廷灸
Metabolic dysfunction-associated fatty liver diseasePhlegm-blood stasis interbinding patternXuanfuhua decoctionGexia Zhuyu TangImperial moxibustion
《中医临床研究》 2026 (7)
49-55,7
铜陵市科技计划项目(20230203065).
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