基于细胞焦亡从"络病理论"探讨特发性肺纤维化的病机与治疗OA
Exploration of the pathogenesis and treatment of idiopathic pulmonary fibrosis from the perspective of"collateral disease theory"based on pyroptosis
文章基于"络病理论"浅析特发性肺纤维化的病机特点,提出"肺热络瘀"是特发性肺纤维化发展过程中的关键病机.细胞焦亡作为特发性肺纤维化发生的重要机制,与"肺热络瘀"病机理论内涵不谋而合.文章通过探讨两者在特发性肺纤维化中的相关性总结对应的中医治法,以期开拓预防与治疗特发性肺纤维化的新途径.
This article briefly analyzes the pathogenesis characteristics of idiopathic pulmonary fibrosis(IPF)from the perspective of the"collateral disease theory",and proposes that"lung heat with collateral stasis"is considered as the key pathogenesis in the development of IPF.As an important mechanism in the occurrence of IPF,pyroptosis shows a high degree of consistency with the theoretical connotation of the"lung heat with collateral stasis"pathogenesis.By exploring the correlation between the two in IPF,this article summarizes the corresponding TCM treatment principles,aiming to open up novel therapeutic approaches for the prevention and treatment of IPF.
王欣宇;郭思佳;娄晨旭;周涵
天津中医药大学研究生院,天津,301617天津中医药大学第二附属医院,天津,300250天津中医药大学研究生院,天津,301617天津中医药大学研究生院,天津,301617
医药卫生
特发性肺纤维化肺热络瘀细胞焦亡络病理论
Idiopathic pulmonary fibrosisLung heat and collaterals stasisPyroptosisCollateral disease theory
《中医临床研究》 2026 (6)
1-6,6
国家自然科学基金项目(81874398).
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