抑郁与卒中共病的异病同治机制:聚焦痰瘀-炎症轴的中西医整合研究OA

Depression and stroke are common neurological disorders with a high comorbidity rate and pathologically interrelated mechanisms,making them a focal point and a major challenge in contemporary brain disease research.While modern medicine has achieved certain advances in anti-inflammatory and neuroprotective therapies,comprehensive regulation of the interrelated pathological network underlying depression-stroke comorbidity remains clinically limited.This is particularly evident in the low response rates and insufficient target engagement efficacy of single-target drugs.Therefore,exploring the biological basis and interventional strategies for depression-stroke comorbidity from an integrated medicine perspective combining Chinese and Western medicine perspective holds significant theoretical innovation value and clinical practical significance.This paper,based on the concept of"integrated of Chinese-Western concept",delves into the correlation between the"inflammation axis"and the"phlegm-stasis"theory,proposing that the"phlegm-stasis-inflammation axis"represents the shared core pathogenesis of both conditions.Traditional Chinese medicine theory posits that the mutual intertwining of phlegm and blood stasis obstructs the orifices and collaterals,potentially disturbing mental clarity to induce depression while also impeding cerebral vessels to cause stroke.This closely corresponds to processes in neuroimmune and inflammatory responses,such as cytokine release and vascular endothelial injury.Thus,the"phlegm-stasis-inflammation axis"not only provides a theoretical framework for understanding the shared pathological basis of these two diseases but also serves as a key entry point for the"treating different diseases with the same therapy"strategy.Concurrently,clinical practice explores the efficacy of targeted therapy with Chinese herbal medicine and TCM external interventions for depression and stroke.This paper integrates modern neuroimmunological mechanisms with TCM phlegm-blood stasis theory,offering novel approaches for the prevention and treatment of depression and stroke through"combining disease patterns with syndrome differentiation"and"treating different diseases with the same therapy".It demonstrates the integrative value of TCM's holistic perspective and syndrome differentiation in managing complex diseases,providing a breakthrough academic framework for cross-disease precision treatment models.