基于数据挖掘含宽筋藤的藏药方剂配伍规律OA

Objective:To explore the compatibility rules of Tibetan ethnomedicinal preparations containing Kuanjinteng(Caulis Tinosporae sinensis)by data mining,so as to provide a reference basis for the research and development of new drugs.Methods:The prescriptions containing Kuanjinteng in Tibetan medical classics were sorted out.A database was established with Microsoft Excel 2019,and then SPSS Modeler 18.0 was applied to analyze the main treated diseases,compatibility combinations,association rules and complex networks of these prescriptions.Results:A total of 135 prescriptions were collected and included,involving 189 species of medicinal materials.The high-frequency compatible medicinal materials included Hezi(Terminalia chebula),Yuganzi(Phyllanthus emblica),Maohezi(Terminalia billerica),etc.There were 32 categories of diseases primarily treated,mainly including Bi syndrome(痹证),gout,and Huangshui disease(黄水病).Most of the high-frequency medicinal materials were bitter in flavor,warm in nature,and sweet in"Sanhuawei"(a unique concept in Tibetan medicine referring to the transformed taste after drug metabolism,not"three-flavored flavors").Additionally,the combination frequency of Kuanjinteng and Hezi was relatively high.Conclusion:Tibetan medicine prescriptions containing Kuanjinteng can treat diseases such as gout and Bi syndrome by exerting effects such as clearing heat and warming the interior.This study is of great significance for exploring the efficacy rules of Tibetan medicine and developing innovative anti-rheumatic drugs.