基于古今医案数据挖掘的肾虚型喘证用药规律探析OA

Objective:To analyze the medication characteristics and rules of traditional Chinese medicines(TCM)used in treating asthma with kidney deficiency syndrome in ancient and modern Chinese medical cases,explore the distribution similarities and differences of drugs used for this syndrome,and provide new ideas and theoretical basis for the application research.Methods:By searching the related literature of asthma with kidney deficiency in CNKI,Wanfang Data,Chinese Medical Canon,and Ancient and Modern Medical Cases Cloud Platform,the database of prescriptions and herbs for this syndrome was established using Excel 2019,and the herb frequency,four natures and five flavor,meridian tropism,efficacy,association rules,complex network and system clustering were analyzed via SPSS Modeler 18.0,Cytoscape 3.10,and Origin 2024.Results:A total of 287 Chinese medicine prescriptions meeting the inclusion criteria were screened out,involving 297 kinds of Chinese medicinal herbs with a cumulative medication frequency of 3 196 times.A total of 42 Chinese medicinal herbs with a usage frequency of≥20 times were identified.Analysis of the nature,flavor,and meridian tropism of the Chinese medicinal herbs showed that in term of four natures,warm-natured herbs had the highest frequency;in term of five flavors,sweet-flavored herbs were the most frequently used;and in terms of meridian tropism,the herbs mainly acted on the lung meridian,liver meridian,and kidney meridian.With the minimum support set at 10%and confidence level≥80%,25 association combinations were obtained.The core formula generated via complex network analysis consisted of Fuling(Poria cocos),Shanzhuyu(Fructus Corni),Shanyao(Rhizoma Dioscoreae),Shudihuang(Radix Rehmanniae Preparata),and Wuweizi(Fructus Schisandrae Chinensis).In addition,5 herb clustering combinations were identified through hierarchical clustering analysis.Conclusion:The treatment of asthma with kidney deficiency syndrome is centered on tonifying kidney and reinforcing Qi(气),giving consideration to invigorating spleen and eliminating dampness,astringing lung and resolving phlegm,and the medication highlights the characteristics of nourishing Yin(阴)and warming Yang(阳),treating both the symptoms and root causes,which fully embodies the idea of"treating spleen and kidney simultaneously".The prescription combination obtained by data mining has good reference value for clinical medication.This study reveals the law of medication for asthma with kidney deficiency syndrome,confirms the theoretical value of"kidney governing Qi"in TCM,and provides data support for clinical optimization of prescription and improvement of diagnosis and treatment effect.