基于伏风理论治疗免疫球蛋白A肾病的临床研究OA
Clinical study on the treatment of IgA nephropathy with the theory of"latent wind pathogen lodged in the body"
目的:本研究旨在探索伏风理论对免疫球蛋白 A(immunoglobulin A,IgA)肾病治疗的指导作用.在既有 IgA 肾病中医病因的基础上进一步探讨风邪内伏是否为 IgA 肾病慢性迁延阶段的重要病因.方法:应用常规辨证论治加祛风药的方法治疗慢性迁延阶段 IgA 肾病病例 30 例,观察常规辨证论治加祛风药是否可以提高IgA 肾病的疗效,进而判断风邪内伏是否为 IgA肾病的重要病因、祛风法是否为中医治疗 IgA 肾病的重要方法.具体方法:选取临床慢性迁延阶段的 IgA 肾病患者 60 例,分为观察组和对照组,每组均为30 例.观察组在常规辨证论治的基础上加祛风药治疗,对照组仅用常规辨证论治的方法治疗.疗程结束后,统计两组病例的证候积分、治疗有效率、尿红细胞计数、24 小时尿蛋白定量及肾小球滤过率(glomerular filtration rate,GFR),作差异对比.结果:治疗结束后,在证候积分方面,观察组略优于对照组,差异无统计学意义(P＞0.05);在治疗有效率方面,观察组优于对照组,差异有统计学意义(P＜0.05);在尿红细胞计数、24 小时尿蛋白定量及 GFR 方面,观察组均优于对照组,差异有统计学意义(P＜0.05).结论:风邪内伏是 IgA 肾病慢性迁延阶段的重要病因,运用祛风药能明显提高 IgA 肾病疗效,包括改善症状、提高有效率和改善肾功能.
Objective:This study aims to explore the guiding role of the latent wind pathogen lodged theory in the treatment of IgA nephropathy(IGAN).Building on the existing traditional Chinese medicine(TCM)etiology of IGAN,it further investigates whether latent wind pathogenis serve as a significant etiological factor in the chronic persistent stage of IGAN.Methods:By applying the method of conventional syndrome differentiation and treatment supplemented with wind-dispersing drugs,30 cases of IGAN in the chronic persistent stage were treated.It was observed whether the combination of conventional syndrome differentiation and wind-dispersing drugs could improve the efficacy of treating IGAN,and thus determine whether the internal accumulation of wind pathogens is an significant etiological factor of IGAN and whether the wind-dispersing method is an important method in TCM treatment of IGAN.Sixty cases of IGAN in the chronic persistent stage were selected and divided into an observation group and a control group,with 30 cases in each.30 cases in the chronic persistent stage in the observation group were treated with wind-dispersing drugs on the basis of conventional syndrome differentiation,while 30 cases in the control group were treated only with conventional syndrome differentiation without wind-dispersing drugs.After the treatment,the syndrome score,therapeutic effective rate,urinary red blood cell count,24-hour urinary protein excretion and glomerular filtration rate of the two groups were observed.Results:In terms of syndrome score,the observation group was marginally better than the control group,with no statistically significant difference(P>0.05),but in terms of total effective rate,urinary red blood cell count,24-hour urinary protein excretion and glomerular filtration rate,the observation group performed significantly better than the control group,with statistically significant differences(P<0.05).Conclusion:Wind pathogen lodged in the body is an important cause of chronic persistent stage of IGAN;the use of wind-dispersing drugs can significantly improve the efficacy in the treatment of IGAN,including symptom amelioration,and therapeutic effective rate and renal function improvement.
肖媛;欧阳晃平
江西中医药大学附属医院,江西 南昌,330006江西中医药大学附属医院,江西 南昌,330006
医药卫生
风邪内伏免疫球蛋白A肾病祛风药临床研究
Latent wind pathogenIgA nephropathyWind-dispersing drugsClinical research
《中医临床研究》 2026 (2)
105-110,6
江西省中医药科技计划项目(2020A0151).
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